The Effects of Exogenous Melatonin on Peripheral Nerve Regeneration and Collagen Formation in Rats

ATİK B., Erkutlu I., Tercan M., Buyukhatipoglu H., Bekerecioglu M., Pence S.

JOURNAL OF SURGICAL RESEARCH, vol.166, no.2, pp.330-336, 2011 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 166 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jss.2009.06.002
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.330-336
  • Istanbul University Affiliated: Yes


Background. Peripheral nerve damage that requires surgical repair does not result in complete recovery because of collagen scar formation, ischemia, free oxygen radical damage, and other factors. To date, the best treatment method has not yet been determined. In this study, we designed an experimental peripheral nerve injury model, and researched the possible effects of melatonin hormone, based on evidence of its strong antioxidant and cell-protective effects via mimicking the effects of calcium channel blockers.