APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI


MISKI M. , SHEN X., COOPER R., GILLUM A., FISHER D., MILLER R., ...More

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.5, pp.1519-1522, 1995 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 14
  • Publication Date: 1995
  • Doi Number: 10.1016/0960-894x(95)00250-w
  • Title of Journal : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Page Numbers: pp.1519-1522

Abstract

Using a high throughput colorimetric bioassay three aporphine alkaloids, annonaine, nornuciferine and roemerine, were isolated and identified as the CD45 protein tyrosine phosphatase inhibitor metabolites of Rollinia ulei. The nor-aporphine alkaloids, anonaine (1) and nornuciferine (3), exhibited more potent inhibitory activity than that of the N-methylated alkaloid roemerin (2).