APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI

MISKI, MAHMUD; SHEN, X; COOPER, R; GILLUM, AM; FISHER, DK; MILLER, RW; HIGGINS, TJ

doi:10.1016/0960-894x(95)00250-w

APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI

MISKI M., SHEN X., COOPER R., GILLUM A., FISHER D., MILLER R., ...Daha Fazla

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.5, sa.14, ss.1519-1522, 1995 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5 Sayı: 14
Basım Tarihi: 1995
Doi Numarası: 10.1016/0960-894x(95)00250-w
Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1519-1522
İstanbul Üniversitesi Adresli: Hayır

Özet

Using a high throughput colorimetric bioassay three aporphine alkaloids, annonaine, nornuciferine and roemerine, were isolated and identified as the CD45 protein tyrosine phosphatase inhibitor metabolites of Rollinia ulei. The nor-aporphine alkaloids, anonaine (1) and nornuciferine (3), exhibited more potent inhibitory activity than that of the N-methylated alkaloid roemerin (2).