APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI

MISKI, Mahmud; SHEN, X; COOPER, R; GILLUM, AM; FISHER, DK; MILLER, RW; HIGGINS, TJ

doi:10.1016/0960-894x(95)00250-w

APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI

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MISKI M., SHEN X., COOPER R., GILLUM A., FISHER D., MILLER R., ...More

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.5, no.14, pp.1519-1522, 1995 (SCI-Expanded)

Publication Type: Article / Article
Volume: 5 Issue: 14
Publication Date: 1995
Doi Number: 10.1016/0960-894x(95)00250-w
Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1519-1522
Istanbul University Affiliated: No

Abstract

Using a high throughput colorimetric bioassay three aporphine alkaloids, annonaine, nornuciferine and roemerine, were isolated and identified as the CD45 protein tyrosine phosphatase inhibitor metabolites of Rollinia ulei. The nor-aporphine alkaloids, anonaine (1) and nornuciferine (3), exhibited more potent inhibitory activity than that of the N-methylated alkaloid roemerin (2).