Akademik Veri Yönetim Sistemi
BIOMARKERS IN MEDICINE, cilt.20, sa.2, ss.87-94, 2026 (SCI-Expanded, Scopus)
Objectives: This study aimed to investigate the predictive value of the C-reactive protein-albumin-lymphocyte (CALLY) index for mortality in patients diagnosed with Infective Endocarditis (IE). Methods: We retrospectively analyzed 100 patients diagnosed with IE based on Duke criteria between 2016 and 2024. The CALLY index was calculated at admission using the formula: [(albumin & times; lymphocyte count)/CRP]. Demographic, clinical, laboratory, and echocardiographic data were collected Results: Mortality occurred in 55% of patients. The deceased group had significantly lower CALLY index values compared to survivors (median: 1.7 vs. 6.9, p < 0.001). Multivariate analysis identified male sex (OR 3.791, p = 0.043), diabetes mellitus (OR 4.126, p = 0.022), and a lower CALLY index (OR 0.824, p = 0.005) as independent predictors of mortality, with lower CALLY values being associated with a higher risk of death. The CALLY index demonstrated moderate discriminative power (AUC = 0.792) with a cutoff value of 3.3, which yielded 68.9% sensitivity and 69.1% specificity. Conclusions: The CALLY index, an accessible and cost-effective biomarker, is independently associated with mortality and may serve as a hypothesis-generating tool for risk stratification in IE patients. Its incorporation into routine clinical assessment may enhance early risk stratification and guide management strategies.