Glutathione S-Transferase M1 and T1 Gene Deletions and Susceptibility to Acute Lymphoblastic Leukemia (ALL) in Adults


Zehra A., Zehra S., Ismail M., Azhar A.

PAKISTAN JOURNAL OF MEDICAL SCIENCES, vol.34, no.3, pp.666-670, 2018 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.12669/pjms.343.14911
  • Journal Name: PAKISTAN JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.666-670
  • Keywords: Acute Lymphoblastic Leukemia, ALL, GSTM1, GSTT1, Genetic, Polymorphism, PROGNOSTIC-FACTORS, CANCER STATISTICS, POLYMORPHISMS, GSTM1, GSTT1, CHILDHOOD, GSTP1, RISK
  • Istanbul University Affiliated: No

Abstract

Objective: Biotransformation of xenobiotics is critical for their metabolism and removal from the body which is carried out by xenobiotic metabolizing enzymes. Individuals carrying variants of genes that encode these enzymes have an altered ability to metabolize xenobiotics which may lead to an increased risk of acute lymphoblastic leukemia. The current study aimed to investigate the impact of GSTM1 and GSTT1 gene deletions in causing predisposition to adult ALL.