Disappearing Inferior Vena Cava in A Pediatric Patient with Down Syndrome and Hereditary Thrombophilia

Petik B., ÇEVİK M. Ö., Sirik M., Colak D., ERTÜRK Ş. M.

JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY, vol.100, no.1, 2016 (SCI-Expanded) identifier

  • Publication Type: Article / Editorial Material
  • Volume: 100 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5334/jbr-btr.975
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Keywords: Disappearing Inferior Vena Cava, Hereditary Thrombophilia, IVC, Down syndrome, homozygous MTHFR polymorphism, CEREBRAL VENOUS THROMBOSIS, FACTOR-V-LEIDEN, CONGENITAL ABSENCE, RISK FACTOR
  • Istanbul University Affiliated: Yes


Absence of the infrarenal segment of the inferior vena cava is an extremely rare anomaly. The reasons for such a developmental failure are unclear. Most researchers believe that the cause lies in embryonic dysgenesis affecting separate segments or the entire inferior vena cava. Others suggest that absence of the inferior vena cava is not embryonic in origin, rather the result of intrauterine or perinatal thrombosis. We report a case here that during a period of six months, inferior vena cava first occluded, then become redundant in a baby girl with several chromosomal and gene defects, including Down syndrome and hereditary thrombophilia, admitted to our hospital due to the swelling and redness of the right lower extremity. From this observation, we propose that the absence of the inferior vena cave was not of embryonic origin but due to thrombosis.