Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations


El-Magadmi M., Alansari A., Teh L., Ordi J., Gul A., Inanc M., ...More

JOURNAL OF RHEUMATOLOGY, vol.28, no.12, pp.2650-2652, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 12
  • Publication Date: 2001
  • Journal Name: JOURNAL OF RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2650-2652
  • Keywords: systemic lupus erythematosus, genetics, association studies, E-selectin, ethnicity, TUMOR-NECROSIS-FACTOR, ATHEROSCLEROSIS, BINDING, DETECTS
  • Istanbul University Affiliated: Yes

Abstract

Objective. E-selectin is expressed on cytokine stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. The gene for E-selectin is located at chromosome 1q23-25 within the linkage area for systemic lupus erythematosus (SLE). The best characterized polymorphism in E-selectin molecule is A561C. which codes for Ser128Arg. We studied the prevalence of the A561C E-selectin gene polymorphism in patients with SLE and controls from 3 different ethnic populations.