PENETRATION OF CIPROFLOXACIN INTO PLEURAL FLUID


UMUT S., DEMIR T., AKKAN G., KESKINER N., YILMAZ V., YILDIRIM N., ...More

JOURNAL OF CHEMOTHERAPY, vol.5, no.2, pp.110-112, 1993 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 2
  • Publication Date: 1993
  • Doi Number: 10.1080/1120009x.1993.11739217
  • Journal Name: JOURNAL OF CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.110-112
  • Istanbul University Affiliated: No

Abstract

The penetration of oral 1000 mg/day ciprofloxacin into pleural fluid is investigated in 15 patients with exudative pleural effusion. After 4 days of ciprofloxacin therapy ciprofloxacin concentrations were measured in plasma and pleural exudate simultaneously by high-performance liquid chromatography (HPLC). Mean serum ciprofloxacin level was 1.58 +/- 0.91 mg/L and mean pleural exudate concentration was 1.00 +/- 0.59 mg/L. The concentrations achieved were all above the MIC90 of the majority of Gram-positive and Gram-negative pathogens. It is concluded that ciprofloxacin penetrates well into the pleural fluid.