2018 update of the EULAR recommendations for the management of Behcet's syndrome


Hatemi G., CHRISTENSEN R., BANG D., BODAGHI B., Celik A. F., Fortune F., ...Daha Fazla

ANNALS OF THE RHEUMATIC DISEASES, cilt.77, sa.6, ss.808-818, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 77 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1136/annrheumdis-2018-213225
  • Dergi Adı: ANNALS OF THE RHEUMATIC DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.808-818
  • Anahtar Kelimeler: behcet's disease, anti-tnf, treatment, LONG-TERM EFFICACY, ANTI-TNF-ALPHA, INTRAVITREAL TRIAMCINOLONE ACETONIDE, HUMAN RECOMBINANT INTERFERON-ALPHA-2A, PULMONARY-ARTERY INVOLVEMENT, NERVOUS-SYSTEM SYMPTOMS, CYSTOID MACULAR EDEMA, DOUBLE-BLIND, REFRACTORY UVEITIS, EXTRAOCULAR MANIFESTATIONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Several new treatment modalities with different mechanisms of action have been studied in patients with Behcet's syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from different specialties including internal medicine, rheumatology, ophthalmology, dermatology, neurology, gastroenterology, oral health medicine and vascular surgery, along with a methodologist, a health professional, two patients and two fellows in charge of the systematic literature search. Research questions were determined using a Delphi approach. EULAR standardised operating procedures was used as the framework. Results of the systematic literature review were presented to the task force during a meeting. The former recommendations were modified or new recommendations were formed after thorough discussions followed by voting. The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added. These updated, evidence-based recommendations are intended to help physicians caring for patients with BS. They also attempt to highlight the shortcomings of the available clinical research with the aim of proposing an agenda for further research priorities.