Polymorphisms of vascular cell adhesion molecule1 (VCAM1) in polycystic ovary syndrome determined by quantitative real-time polymerase chain reaction and melting curve analysis


Kanmaz-Ozer M., Vural P. , Dogru-Abbasoglu S. , GEDIKBASI A., CIL E., KARADAG B., ...Daha Fazla

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.160, ss.174-178, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 160 Konu: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.ejogrb.2011.11.013
  • Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Sayfa Sayıları: ss.174-178

Özet

Objective: Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with increased risk of obesity, insulin resistance (IR) and type 2 diabetes mellitus. Low-grade chronic inflammation and imbalance between pro- and anti-inflammatory cytokines has been proposed to play a role in the pathogenesis. Vascular cell adhesion molecule1 (VCAM1) is among the parameters reflecting low-grade chronic inflammation whose expression is increased by pro-inflammatory cytokines. This study examined the possible association of T-1591C and T-833C single nucleotide polymorphisms (SNPs) of VCAM1 gene with the occurrence and the clinical/biochemical characteristics of PCOS.