Polymorphisms of vascular cell adhesion molecule1 (VCAM1) in polycystic ovary syndrome determined by quantitative real-time polymerase chain reaction and melting curve analysis

Kanmaz-Ozer, Muge; Vural, Pervin; Dogru-Abbasoglu, Semra; GEDIKBASI, Ali; CIL, Esra; KARADAG, Berrin; Uysal, Mujdat

doi:10.1016/j.ejogrb.2011.11.013

Polymorphisms of vascular cell adhesion molecule1 (VCAM1) in polycystic ovary syndrome determined by quantitative real-time polymerase chain reaction and melting curve analysis

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Kanmaz-Ozer M., Vural P., Dogru-Abbasoglu S., GEDIKBASI A., CIL E., KARADAG B., ...More

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.160, no.2, pp.174-178, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 160 Issue: 2
Publication Date: 2012
Doi Number: 10.1016/j.ejogrb.2011.11.013
Journal Name: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.174-178
Istanbul University Affiliated: Yes

Abstract

Objective: Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with increased risk of obesity, insulin resistance (IR) and type 2 diabetes mellitus. Low-grade chronic inflammation and imbalance between pro- and anti-inflammatory cytokines has been proposed to play a role in the pathogenesis. Vascular cell adhesion molecule1 (VCAM1) is among the parameters reflecting low-grade chronic inflammation whose expression is increased by pro-inflammatory cytokines. This study examined the possible association of T-1591C and T-833C single nucleotide polymorphisms (SNPs) of VCAM1 gene with the occurrence and the clinical/biochemical characteristics of PCOS.