Mucoepidermoid Carcinoma of the Parotid Gland in Childhood Survivor of Acute Lymphoblastic Leukemia With Need of Radiotherapy for Treatment and Review of the Literature

Tugcu D., Akici F., Aydogan G., Salcioglu Z., Akcay A., Sen H., ...More

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.29, no.4, pp.380-385, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Letter
  • Volume: 29 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.3109/08880018.2012.673696
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.380-385
  • Keywords: acute leukemia, mucoepidermoid carcinoma, parotid gland, second cancer, 2ND MALIGNANT NEOPLASMS, TUMORS, CHILDREN, CANCER, NECK, HEAD
  • Istanbul University Affiliated: Yes


Diagnosis of secondary malignancies began with the increasing survival in childhood cancer. Children treated for acute lymphoblastic leukemia (ALL) have an increased risk for developing mucoepidermoid carcinoma (MEC) of the parotid gland. The latent period ranges from 5 to 16 years. A 2 6/12-year-old girl was treated for pro-B ALL. Treatment included multidrug chemotherapy, prophylactic intrathecal methotrexate, and cranial radiotherapy. MEC of the left parotid gland was diagnosed at the age of 8 years, 3 years after completing treatment. She was treated with multiple surgery and radiotherapy. The authors aimed to emphasize the need for concern about second cancers of the parotid gland in children treated for ALL.