The role of K-RAS and B-RAF mutations as biomarkers in metastatic colorectal cancer

Selcukbiricik F., Erdamar S., Ozkurt C. U., Mandel N. M., Demirelli F. H., Ozguroglu M., ...More

JOURNAL OF BUON, vol.18, no.1, pp.116-123, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2013
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.116-123
  • Istanbul University Affiliated: Yes

Abstract

Purpose: Unlike cetuximab, there is a paucity of biomarkers for bevacizumab as predictors of outcome in metastatic colorectal cancer (mCRC) patients. Obviously exploring the worth of some potential markers in this setting is warranted. The purpose of this study was to investigate the predictive value of the presence of K-RAS and B-RAF mutations on the outcome of patients with mCRC treated with FOLFIRI and bevacizumab combination therapy.