A comparative study of obsessive-compulsive disorder and other psychiatric comorbidities in patients with temporal lobe epilepsy and idiopathic generalized epilepsy

Ertekin B. A. , Kulaksizoglu I. B. , Ertekin E., Gurses C., Bebek N. , Gokyigit A., ...More

EPILEPSY & BEHAVIOR, vol.14, no.4, pp.634-639, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1016/j.yebeh.2009.01.016
  • Title of Journal : EPILEPSY & BEHAVIOR
  • Page Numbers: pp.634-639


Our aim was to assess the associations of temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE) with comorbid psychiatric conditions, especially obsessive-compulsive disorder (OCD), in a comparative design. We evaluated 29 patients with TLE, 27 patients with ICE, and 30 healthy controls. The Structured Clinical Interview for DSM-IV (SCID), Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Symptom Checklist, and Beck Depression Inventory (BDI) were administered. Among patients with TLE, 75.9%, and among patients with ICE, 48.1% had at least one Axis 1 psychiatric disorder. Clinically meaningful obsessive-compulsive symptoms (CM-OCS) were noted in 10 patients with TLE and in 3 patients with ICE, and this difference was statistically significant (P < 0.05). CM-OCS were present in 9 of 18 patients with left-sided TLE, but in only 1 of 11 patients with right-sided TLE. Higher comorbidity in TLE Suggests that involvement of the temporal lobe may play a role in the development of specific psychopathological syndromes. (C) 2009 Elsevier Inc. All rights reserved.