Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial - Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial

HOUSSIAU, FA; VASCONCELOS, C; D'CRUZ, D; SEBASTIANI, GD; GARRIDO, ED; DANIELI, MG; ABRAMOVICZ, D; BLOCKMANS, D; MATHIEU, A; DIRESKENELI, H; GALEAZZI, M; Gul, AHMET; LEVY, Y; PETERA, P; POPOVIC, R; PETROVIC, R; SINICO, RA; CATTANEO, R; FONT, J; DEPRESSEUX, GV; COSYNS, JP; CERVERA, R

doi:10.1002/art.20666

Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial - Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial

HOUSSIAU F., VASCONCELOS C., D'CRUZ D., SEBASTIANI G., GARRIDO E., DANIELI M., ...More

ARTHRITIS AND RHEUMATISM, vol.50, no.12, pp.3934-3940, 2004 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 50 Issue: 12
Publication Date: 2004
Doi Number: 10.1002/art.20666
Journal Name: ARTHRITIS AND RHEUMATISM
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.3934-3940
Istanbul University Affiliated: Yes

Abstract

Objective. In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors.