Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial - Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial

HOUSSIAU, FA; VASCONCELOS, C; D'CRUZ, D; SEBASTIANI, GD; GARRIDO, ED; DANIELI, MG; ABRAMOVICZ, D; BLOCKMANS, D; MATHIEU, A; DIRESKENELI, H; GALEAZZI, M; Gul, Ahmet; LEVY, Y; PETERA, P; POPOVIC, R; PETROVIC, R; SINICO, RA; CATTANEO, R; FONT, J; DEPRESSEUX, GV; COSYNS, JP; CERVERA, R

doi:10.1002/art.20666

Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial - Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial

Atıf İçin Kopyala

HOUSSIAU F., VASCONCELOS C., D'CRUZ D., SEBASTIANI G., GARRIDO E., DANIELI M., ...Daha Fazla

ARTHRITIS AND RHEUMATISM, cilt.50, sa.12, ss.3934-3940, 2004 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 50 Sayı: 12
Basım Tarihi: 2004
Doi Numarası: 10.1002/art.20666
Dergi Adı: ARTHRITIS AND RHEUMATISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.3934-3940
İstanbul Üniversitesi Adresli: Evet

Özet

Objective. In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors.