Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine

Creative Commons License

Gok M. K., Ozgumus S., Demir K., Cirit U., Pabuccuoglu S., Cevher E., ...More

CARBOHYDRATE POLYMERS, vol.136, pp.63-70, 2016 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 136
  • Publication Date: 2016
  • Doi Number: 10.1016/j.carbpol.2015.08.079
  • Journal Name: CARBOHYDRATE POLYMERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.63-70
  • Keywords: Vaginal drug delivery, Mucoadhesion, Starch, Acrylic acid, Progesterone, Estrus synchronization, IN-VITRO EVALUATION, THIOLATED POLYMERS, PROGESTERONE, COPOLYMERS, ACID
  • Istanbul University Affiliated: Yes

Abstract

tThe aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradableprogesterone containing vaginal tablets based on modified starch copolymers for the estrus synchroniza-tion of ewes. Starch-graft-poly(acrylic acid) copolymers (S-g-PAA) were synthesized and characterized.The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrixerosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tabletswere investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitroand in vivo progesterone release profiles from the tablets were compared with two commercial products.Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)gcindicated promis-ing results and might be convenient as an alternative product to the commercial products in veterinarymedicine.

The aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly( acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)(gc) indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine. (C) 2015 Elsevier Ltd. All rights reserved.