CARBOHYDRATE POLYMERS, cilt.136, ss.63-70, 2016 (SCI-Expanded)
tThe aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradableprogesterone containing vaginal tablets based on modified starch copolymers for the estrus synchroniza-tion of ewes. Starch-graft-poly(acrylic acid) copolymers (S-g-PAA) were synthesized and characterized.The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrixerosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tabletswere investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitroand in vivo progesterone release profiles from the tablets were compared with two commercial products.Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)gcindicated promis-ing results and might be convenient as an alternative product to the commercial products in veterinarymedicine.