Pleiotropic effects of pitavastatin: a pilot study using the saphenous vein endothelial cell model of endothelial injury and prevention of atherosclerosis

Onal B., Alaylioglu M., Yenmis G., Dogan A. S., Dursun E., Gezen-Ak D., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.26, sa.14, ss.5210-5217, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 14
  • Basım Tarihi: 2022
  • Doi Numarası: 10.26355/eurrev_202207_29310
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.5210-5217
  • Anahtar Kelimeler: Cardiovascular diseases, Atherosclerosis, Atorvastatin, Pitavastatin, Inflammation, KAPPA-B, ATORVASTATIN, EXPRESSION, STATINS, ALPHA, CHOLESTEROL, DISEASE, TNF
  • İstanbul Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Cardiovascular diseases are responsible for the majority of deaths on a global scale. Atherosclerosis is the main risk factor for cardiovascular disorders and represents a complex phenomenon associated with endothelial dysfunction and inflammation. Statins, especially atorvastatin (ATV) and pitavastatin (PTV), are common agents used to control ongoing atherosclerotic events in the body to minimize cardiovascular disease-based deaths.