Pleiotropic effects of pitavastatin: a pilot study using the saphenous vein endothelial cell model of endothelial injury and prevention of atherosclerosis

Onal B., Alaylioglu M., Yenmis G., Dogan A. S., Dursun E., Gezen-Ak D., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.26, no.14, pp.5210-5217, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 14
  • Publication Date: 2022
  • Doi Number: 10.26355/eurrev_202207_29310
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.5210-5217
  • Keywords: Cardiovascular diseases, Atherosclerosis, Atorvastatin, Pitavastatin, Inflammation, KAPPA-B, ATORVASTATIN, EXPRESSION, STATINS, ALPHA, CHOLESTEROL, DISEASE, TNF
  • Istanbul University Affiliated: Yes

Abstract

OBJECTIVE: Cardiovascular diseases are responsible for the majority of deaths on a global scale. Atherosclerosis is the main risk factor for cardiovascular disorders and represents a complex phenomenon associated with endothelial dysfunction and inflammation. Statins, especially atorvastatin (ATV) and pitavastatin (PTV), are common agents used to control ongoing atherosclerotic events in the body to minimize cardiovascular disease-based deaths.