The induction of oxidative stress, cytotoxicity, and genotoxicity by dental adhesives

Demirci M., Hiller K. -., Bosl C., Galler K., Schmalz G., Schweikl H.

DENTAL MATERIALS, vol.24, no.3, pp.362-371, 2008 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.dental.2007.06.009
  • Journal Name: DENTAL MATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.362-371
  • Keywords: dental adhesives, cytotoxicity, genotoxicity, reactive oxygen species, IN-VITRO CYTOTOXICITY, CELL-CYCLE ARREST, HUMAN PULP CELLS, BONDING AGENTS, GINGIVAL FIBROBLASTS, RESIN MONOMERS, ROS PRODUCTION, T-ANTIGEN, APOPTOSIS, ACRYLAMIDE
  • Istanbul University Affiliated: Yes

Abstract

Objectives. Polymerized dental resin materials release residual monomers that may interact with pulp tissues. We hypothesized that dental adhesives might cause cytotoxicity in pulp cells via the generation of reactive oxygen species (ROS), which may also contribute to genotoxic effects in vitro.