Effects of Bone Morphogenetic Proteins on Osteoblast Cells: Vascular Endothelial Growth Factor, Calcium, Inorganic Phosphate, and Nitric Oxide Levels

Emes Y., Aybar B., Vural P., Saral N. Y., Atalay B., Kaya A. S., ...More

IMPLANT DENTISTRY, vol.19, no.5, pp.419-427, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1097/id.0b013e3181e5d5d4
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.419-427
  • Istanbul University Affiliated: Yes


Purpose: Bone morphogenetic proteins (BMPs) play an important role in the initiation of bone formation by affecting cell growth and differentiation in a variety of cell types including osteoblasts. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and vasculogenesis, and also, VEGF signaling is important for skeletal development. Nitric oxide (NO), calcium (Ca), and inorganic Phosphate (Pi) are important molecules for cell functions. In this study, the effects of BMP on VEGF, Ca, NO, and Pi levels were investigated in an osteoblast cell culture.