Neutrophil-lymphocyte and platelet-lymphocyte ratios as inflammation markers for bipolar disorder

Kalelioglu T., Akkus M., Karamustafalioglu N., Genc A., Genc E. S., Cansiz A., ...More

PSYCHIATRY RESEARCH, vol.228, no.3, pp.925-927, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 228 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1016/j.psychres.2015.05.110
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.925-927
  • Istanbul University Affiliated: Yes


In the present study we investigated the involvement of inflammatory cells and their ratios as inflammation markers in Bipolar Disorder. We have enrolled 61 manic, 55 euthymic patients and 54 control subjects to the study. Neutrophil-lymphocyte and platelet-lymphocyte ratios were found significantly higher in both manic and euthymic patients compared to control group. These findings suggest that the inflammatory cells have a role in the pathophysiology of bipolar disorder manic and even in euthymic state. (C) 2015 Elsevier Ireland Ltd. All rights reserved.