CLINICAL CANCER RESEARCH, cilt.14, sa.24, ss.8152-8160, 2008 (SCI-Expanded)
Purpose: ATP-binding cassette sub-family C member 2 [ABCC2; multidrug resistance associated protein 2 (MRP2)] and ABCC3 (MRP3) mediate the elimination of toxic compounds, such as drugs and carcinogens, and have a large overlap in substrate specificity. We investigated the roles of Abcc2 and Abcc3 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) in vivo.