Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate

Vlaming M. L. H. , Pala Z. , van Esch A., Wagenaar E., van Tellingen O., de Waart D. R. , ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.14, ss.8152-8160, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Konu: 24
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1158/1078-0432.ccr-08-1609
  • Sayfa Sayıları: ss.8152-8160


Purpose: ATP-binding cassette sub-family C member 2 [ABCC2; multidrug resistance associated protein 2 (MRP2)] and ABCC3 (MRP3) mediate the elimination of toxic compounds, such as drugs and carcinogens, and have a large overlap in substrate specificity. We investigated the roles of Abcc2 and Abcc3 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) in vivo.