Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate

Vlaming, Maria; Pala, Zeliha; van Esch, Anita; Wagenaar, Els; van Tellingen, Olaf; de Waart, Dirk; Elferink, Ronald; van de Wetering, Koen; Schinkel, Alfred

doi:10.1158/1078-0432.ccr-08-1609

Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate

Vlaming M. L. H., Pala Z., van Esch A., Wagenaar E., van Tellingen O., de Waart D. R., ...More

CLINICAL CANCER RESEARCH, vol.14, no.24, pp.8152-8160, 2008 (SCI-Expanded)

Publication Type: Article / Article
Volume: 14 Issue: 24
Publication Date: 2008
Doi Number: 10.1158/1078-0432.ccr-08-1609
Journal Name: CLINICAL CANCER RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.8152-8160
Istanbul University Affiliated: Yes

Abstract

Purpose: ATP-binding cassette sub-family C member 2 [ABCC2; multidrug resistance associated protein 2 (MRP2)] and ABCC3 (MRP3) mediate the elimination of toxic compounds, such as drugs and carcinogens, and have a large overlap in substrate specificity. We investigated the roles of Abcc2 and Abcc3 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) in vivo.