Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4‐thiazolidinone and 1,2,4‐triazole‐3‐thione derivatives

Dincel E. D., Ulusoy-Güzeldemirci N., Şatana D., Küçükbasmacı Ö.

Journal Of Heterocyclic Chemistry, cilt.58, sa.1, ss.195-205, 2021 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 1
  • Basım Tarihi: 2021
  • Dergi Adı: Journal Of Heterocyclic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, EMBASE
  • Sayfa Sayıları: ss.195-205
  • İstanbul Üniversitesi Adresli: Evet

Özet

A series of novel hydrazinecarbothioamide (5a,c,f), 4‐thiazolidinone (6a‐e), and 1,2,4‐triazole‐3‐thione (7a‐d) were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H‐NMR, 13C‐NMR, mass and elemental analysis. All novel derivatives were evaluated for their antibacterial and antifungal activities against nine diverse microorganisms. According to the biological activity studies of the compounds, 6d, 7c and 7d displayed hope promising antibacterial activity. Furthermore, 6d displayed potent antifungal activity. Consequently, the obtained results revealed that 6d, 7c and 7d present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.