Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4‐thiazolidinone and 1,2,4‐triazole‐3‐thione derivatives


Dincel E. D. , Ulusoy-Güzeldemirci N. , Şatana D. , Küçükbasmacı Ö.

Journal Of Heterocyclic Chemistry, vol.58, pp.195-205, 2021 (Journal Indexed in SCI)

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2021
  • Title of Journal : Journal Of Heterocyclic Chemistry
  • Page Numbers: pp.195-205

Abstract

A series of novel hydrazinecarbothioamide (5a,c,f), 4‐thiazolidinone (6ae), and 1,2,4‐triazole‐3‐thione (7ad) were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H‐NMR, 13C‐NMR, mass and elemental analysis. All novel derivatives were evaluated for their antibacterial and antifungal activities against nine diverse microorganisms. According to the biological activity studies of the compounds, 6d7c and 7d displayed hope promising antibacterial activity. Furthermore, 6d displayed potent antifungal activity. Consequently, the obtained results revealed that 6d7c and 7d present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.