Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY, cilt.61, sa.5, ss.721-725, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61 Sayı: 5
- Basım Tarihi: 2008
- Doi Numarası: 10.1007/s00280-007-0526-4
- Dergi Adı: CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.721-725
- Anahtar Kelimeler: metronomic chemotherapy, MTD chemotherapy, serum, VEGF, TSP1, ANGIOGENESIS
- İstanbul Üniversitesi Adresli: Evet
Özet
Background Angiogenesis is regulated by a balance of both angiogenic inducers and inhibitors. This study was designed to evaluate the effect of both maximum-tolerated doses (MTD) and low-dose metronomic chemotherapy (LDM) on serum vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1) and VEGFR1 concentrations in patients with advanced nonsmall cell lung cancer.