Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer


Tas F., Duranyildiz D., Soydinc H. O., Cicin I., Selam M., Uygun K., ...More

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.61, no.5, pp.721-725, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1007/s00280-007-0526-4
  • Journal Name: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.721-725
  • Keywords: metronomic chemotherapy, MTD chemotherapy, serum, VEGF, TSP1, ANGIOGENESIS
  • Istanbul University Affiliated: Yes

Abstract

Background Angiogenesis is regulated by a balance of both angiogenic inducers and inhibitors. This study was designed to evaluate the effect of both maximum-tolerated doses (MTD) and low-dose metronomic chemotherapy (LDM) on serum vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1) and VEGFR1 concentrations in patients with advanced nonsmall cell lung cancer.