Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer


Tas F. , Duranyildiz D. , Soydinc H. O. , Cicin I., Selam M., Uygun K., ...Daha Fazla

CANCER CHEMOTHERAPY AND PHARMACOLOGY, cilt.61, ss.721-725, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00280-007-0526-4
  • Dergi Adı: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Sayfa Sayıları: ss.721-725

Özet

Background Angiogenesis is regulated by a balance of both angiogenic inducers and inhibitors. This study was designed to evaluate the effect of both maximum-tolerated doses (MTD) and low-dose metronomic chemotherapy (LDM) on serum vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1) and VEGFR1 concentrations in patients with advanced nonsmall cell lung cancer.