Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases

Mucci A., MERLOTTI E., Ucok A., ALEMAN A., Galderisi S.

SCHIZOPHRENIA RESEARCH, cilt.186, ss.19-28, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 186
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.schres.2016.05.014
  • Dergi Adı: SCHIZOPHRENIA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.19-28
  • İstanbul Üniversitesi Adresli: Evet

Özet

Primary and persistent negative symptoms (PPNS) represent an unmet need in the care of people with schizophrenia. They have an unfavourable impact on real-life functioning and do not respond to available treatments. Underlying etiopathogenetic mechanisms of PPNS are still unknown. The presence of primary and enduring negative symptoms characterizes deficit schizophrenia (DS), proposed as a separate disease entity with respect to non-deficit schizophrenia (NDS). More recently, to reduce the heterogeneity of negative symptoms by using criteria easily applicable in the context of clinical trials, the concept of persistent negative symptoms (PNS) was developed.