Antibacterial Activities of Pyrenylated Coumarins from the Roots of Prangos hulusii

Tan N., Yazici-Tutunis S., Bilgin M., Tan E., Miski M.

MOLECULES, cilt.22, sa.7, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3390/molecules22071098
  • Dergi Adı: MOLECULES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Prangos hulusii, pyrenylated coumarins, antibacterial activity, GAMMA-PYRONE DERIVATIVES, STRUCTURE ELUCIDATION, CONSTITUENTS, PABULARIA, CHROMONES
  • İstanbul Üniversitesi Adresli: Evet

Özet

The dichloromethane extract of the roots of Prangos hulusii, a recently described endemic species from Turkey, has yielded nine known and one new prenylated coumarins. The structures were elucidated by spectroscopic methods and direct comparison with the reference compounds where available. The root extract and its prenylated coumarins exhibit antimicrobial activity against nine standard and six clinically isolated strains at a concentration between 5 and 125 mu g/mL. In particular, the new coumarin, 4'-senecioiloxyosthol (1), displayed 5 mu g/mL MIC (Minimum Inhibitory Concentration) value against Bacillus subtilis ATCC 9372, murraol (4) and auraptenol (5) showed 63 mu g/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372, and isoimperatorin (9) exhibited 16 mu g/mL MIC value.