TP53 Arg72Pro polymorphism in Turkish patients with sporadic amyotrophic lateral sclerosis

ERGÜL E., Ozel M. D., SAZCI A., Idrisoglu H. A.

NEUROBIOLOGY OF AGING, cilt.32, sa.11, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.neurobiolaging.2011.05.021
  • Dergi Adı: NEUROBIOLOGY OF AGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Recently, Eve et al. (2007) reported that the expression of TP53 (NM_000546) was increased by 2.1-fold in whole spinal cord and 2.7-fold in the ventral horn of amyotrophic lateral sclerosis (ALS) patients. Based on this particular observation, we decided to evaluate whether the TP53 Arg72Pro polymorphism (rs1042522) (C215G) was implicated in the etiopathology of sporadic amyotrophic lateral sclerosis (SALS). Therefore, we genotyped 394 Turkish SALS patients and 439 matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We did not find any association between overall SALS patients with the TP53 Arg72Pro polymorphism and controls (chi(2) = 2.674; p = 0.263). Consequently the TP53 Arg72Pro polymorphism was not associated with SALS. (C) 2011 Elsevier Inc. All rights reserved.