Brain Infiltration of Immune Cells in CASPR2-Antibody Associated Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.53, no.4, pp.344-347, 2016 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 53 Issue: 4
- Publication Date: 2016
- Doi Number: 10.5152/npa.2016.15932
- Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.344-347
- Keywords: Antibody, CASPR2, hippocampal sclerosis, temporal lobe epilepsy, autoimmunity, ANTI-NMDAR ENCEPHALITIS, LIMBIC ENCEPHALITIS, FOCAL EPILEPSY, ANTIBODIES, AUTOANTIBODIES, COMPLEMENT
- Istanbul University Affiliated: Yes
Abstract
Introduction: Antibodies directed against neuronal surface antigens have recently been identified in patients with focal temporal lobe epilepsy (TLE) of unknown cause and mesial TLE with hippocampal sclerosis (MTLE-HS), thereby emphasizing the role of autoimmunity in TLE. Antibodies to contactin-associated protein-like 2 (CASPR2) are prevalent in MTLE-HS patients. We aimed to find out whether anti-neuronal autoimmunity might be involved in CASPR2 antibodyrelated MTLE-HS.