The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy

Akman O., Gulcebi M. I., Carcak N., Ozatman S. K., Eryigit T., Moshe S. L., ...More

EPILEPSIA, vol.56, no.11, pp.1793-1802, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 11
  • Publication Date: 2015
  • Doi Number: 10.1111/epi.13204
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1793-1802
  • Keywords: GAERS, Kindling resistance, Substantia nigra pars reticulata, Tyrosine hydroxylase, Parvalbumin, DEVELOPMENTAL REGULATION, TYROSINE-HYDROXYLASE, GABA(A) RECEPTOR, WAVE DISCHARGES, BASAL GANGLIA, SEIZURES, NEURONS, MICROINFUSIONS, ORGANIZATION, STIMULATION
  • Istanbul University Affiliated: Yes

Abstract

ObjectiveGenetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by kindling. The substantia nigra pars reticulata (SNR) is involved in the propagation and modulation of seizures in kindling. We first examined the role of the SNRanterior and SNRposterior subregions in the resistance to the development of kindling in GAERS. Subsequently, to determine whether kindling resistance relates to differential sensitivity of -aminobutyric acid -aminobutyric acid (GABA)ergic or dopaminergic SNR neurons to kindling, we studied the effects of kindling-inducing stimulations on parvalbumin (PRV; GABAergic neuron marker) or tyrosine hydroxylase (TH; dopaminergic neuron marker) immunoreactivity (ir), respectively, in GAERS and in nonepileptic control (NEC) Wistar rats that lack kindling resistance.