Akademik Veri Yönetim Sistemi
4.Ulusal Karbon Konferansı, İstanbul, Türkiye, 28 - 29 Mart 2024, ss.42-43
Paracetamol (N-acetyl-p-aminophenol, PAR) is an antipyretic and analgesic drug active ingredient
widely used for pain relief and fever reduction. (1). Ibuprofen ((RS)-2-(4-(2-
methylpropyl)phenyl)propanoic acid, IBU) is a non-steroidal anti-inflammatory agent representing a
broad group of drugs that are administered as pain-relieving and antipyretic agents. Both of these
medicines are available without a prescription and are among the most widely sold medicines
worldwide (2). However, an overdose of the two medicines can cause harm to consumers due to
side effects such as nausea and vomiting, which can occur after a while after an overdose, and the
magnitude of the damage may increase in the future. Pain in the liver area, yellowing of the whites of
the eyes and skin, and dark urine output are observed some time after an overdose of these two
medicines (3). For these reasons, it is very important to analyze and evaluate the drug content. The
methods applied for the simultaneous determination of PAR and IBU are generally chromatographic
and spectroscopic, and their costs are quite high compared to electroanalytical methods (4). In
addition, on-site analysis is not possible with these methods, which require expert users.
The aim of this study was to develop a novel electrochemical sensor for the simultaneous
determination of PAR and IBU using a glassy carbon electrode surface modified with Nafion mixed
with graphene with high surface area. Different ratios of graphene and nafion were prepared for the
optimum electrode content to have maximum response.