Effects of Luteolin on Liver, Kidney and Brain in Pentylentetrazol-Induced Seizures: Involvement of Metalloproteinases and NOS Activities

Birman H., Dar K. A., Kapucu A., Acar S., Uzum G.

BALKAN MEDICAL JOURNAL, vol.29, pp.188-196, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29
  • Publication Date: 2012
  • Doi Number: 10.5152/balkanmedj.2011.030
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.188-196
  • Keywords: Luteolin, pentylentetrazol, seizure, metalloproteinases, NOS, NITRIC-OXIDE SYNTHASE, MYOCARDIAL-ISCHEMIA, FLAVONOID QUERCETIN, RATS, MATRIX-METALLOPROTEINASE-9, EXPRESSION, CELLS, EPILEPTOGENESIS, ANTICONVULSANT, DYSFUNCTION
  • Istanbul University Affiliated: Yes

Abstract

Objective: Flavonoids are an important group of recognized antioxidants in plants. Luteolin (LUT) is a natural flavonoid in the plant kingdom. This study was aimed to investigate the effects of the LUT in the liver, kidney and brain of pentylentetrazol (PTZ)-induced seizure and the relationship between nitric oxide synthases (iNOS, eNOS) and matrix metalloproteinases (MMP2, MMP9).