Effects of Luteolin on Liver, Kidney and Brain in Pentylentetrazol-Induced Seizures: Involvement of Metalloproteinases and NOS Activities
BALKAN MEDICAL JOURNAL, cilt.29, ss.188-196, 2012 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29
- Basım Tarihi: 2012
- Doi Numarası: 10.5152/balkanmedj.2011.030
- Dergi Adı: BALKAN MEDICAL JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.188-196
- Anahtar Kelimeler: Luteolin, pentylentetrazol, seizure, metalloproteinases, NOS, NITRIC-OXIDE SYNTHASE, MYOCARDIAL-ISCHEMIA, FLAVONOID QUERCETIN, RATS, MATRIX-METALLOPROTEINASE-9, EXPRESSION, CELLS, EPILEPTOGENESIS, ANTICONVULSANT, DYSFUNCTION
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective: Flavonoids are an important group of recognized antioxidants in plants. Luteolin (LUT) is a natural flavonoid in the plant kingdom. This study was aimed to investigate the effects of the LUT in the liver, kidney and brain of pentylentetrazol (PTZ)-induced seizure and the relationship between nitric oxide synthases (iNOS, eNOS) and matrix metalloproteinases (MMP2, MMP9).