Effects of Luteolin on Liver, Kidney and Brain in Pentylentetrazol-Induced Seizures: Involvement of Metalloproteinases and NOS Activities

Birman H. , Dar K. A. , Kapucu A. , Acar S., Uzum G.

BALKAN MEDICAL JOURNAL, vol.29, pp.188-196, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29
  • Publication Date: 2012
  • Doi Number: 10.5152/balkanmedj.2011.030
  • Title of Journal : BALKAN MEDICAL JOURNAL
  • Page Numbers: pp.188-196


Objective: Flavonoids are an important group of recognized antioxidants in plants. Luteolin (LUT) is a natural flavonoid in the plant kingdom. This study was aimed to investigate the effects of the LUT in the liver, kidney and brain of pentylentetrazol (PTZ)-induced seizure and the relationship between nitric oxide synthases (iNOS, eNOS) and matrix metalloproteinases (MMP2, MMP9).