Primary central nervous system lymphoma: The role of consolidation treatment after a complete response to high-dose methotrexate-based chemotherapy


Ekenel M. , IWAMOTO F. M. , BEN-PORAT L. S. , PANAGEAS K. S. , YAHALOM J., DEANGELIS L. M. , ...More

CANCER, vol.113, pp.1025-1031, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 113 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1002/cncr.23670
  • Title of Journal : CANCER
  • Page Numbers: pp.1025-1031

Abstract

BACKGROUND. The most effective treatment for a new diagnosis of primary central nervous system lymphoma is high-close methotrexate (MTX)-based chemotherapy followed by whole-brain radiation therapy (WBRT). However, this combined modality treatment carries an increased risk of delayed neurotoxicity. For patients who achieve a complete response (CR) after induction that uses high-dose MTX-based chemotherapy, it is not clear if consolidation treatment is necessary. Therefore, a retrospective study was conducted to assess the impact of consolidation treatment after a CR to initial induction chemotherapy on disease control and survival.