INTERNATIONAL IMMUNOPHARMACOLOGY, vol.18, no.1, pp.198-202, 2014 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Graves' disease, Endothelin family, Polymorphism, Angiogenesis, Autoantibody, Ophthalmopathy, GENE LYS198ASN POLYMORPHISM, CELL-PROLIFERATION, BLOOD-PRESSURE, GROWTH-FACTOR, NITRIC-OXIDE, KAPPA-B, ASSOCIATION, NEOVASCULARIZATION, EXPRESSION, VARIANTS
Istanbul University Affiliated:
Purpose: Endothelin 1 (EDN1) is a strong angiogenic and mitogenic factor, playing a key role in hypervascularization, thyroid follicle cell hyperplasia, and lymphocyte infiltration in the thyroid gland of patients with Graves' disease (GD). EDN1 induces angiogenesis and mitogenesis via endothelin receptor type A (EDNRA). This study examined the possible association of EDN1 (G5665T and T-1370G) and EDNRA (C+ 70G and G-231A) single nucleotide polymorphisms (SNPs) with the occurrence of GD, and evaluates the relationship between genotypes and clinical/laboratory manifestations of GD.