Polymorphisms of endothelin 1 (G5665T and T-1370G) and endothelin receptor type A (C+70G and G-231A) in Graves' disease

Aydın A. F., Develi-Is S., Dogru-Abbasoglu S., Vural P., OZDERYA A., KARADAG B., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.18, no.1, pp.198-202, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.intimp.2013.11.017
  • Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.198-202
  • Keywords: Graves' disease, Endothelin family, Polymorphism, Angiogenesis, Autoantibody, Ophthalmopathy, GENE LYS198ASN POLYMORPHISM, CELL-PROLIFERATION, BLOOD-PRESSURE, GROWTH-FACTOR, NITRIC-OXIDE, KAPPA-B, ASSOCIATION, NEOVASCULARIZATION, EXPRESSION, VARIANTS
  • Istanbul University Affiliated: Yes

Abstract

Purpose: Endothelin 1 (EDN1) is a strong angiogenic and mitogenic factor, playing a key role in hypervascularization, thyroid follicle cell hyperplasia, and lymphocyte infiltration in the thyroid gland of patients with Graves' disease (GD). EDN1 induces angiogenesis and mitogenesis via endothelin receptor type A (EDNRA). This study examined the possible association of EDN1 (G5665T and T-1370G) and EDNRA (C+ 70G and G-231A) single nucleotide polymorphisms (SNPs) with the occurrence of GD, and evaluates the relationship between genotypes and clinical/laboratory manifestations of GD.