The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes

Bekpinar S., Yenidunya G., Gurdol F., Unlucerci Y., Aycan-Ustyol E., Dinccag N.

CLINICAL BIOCHEMISTRY, cilt.48, sa.18, ss.1264-1267, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 18
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.clinbiochem.2015.08.001
  • Dergi Adı: CLINICAL BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1264-1267
  • Anahtar Kelimeler: Sphingosine 1-phosphate, Diabetic nephropathy, Apoprotein M, Symmetric dimethylarginine, Asymmetric dimethylarginine, Albuminuria, ENDOTHELIAL BARRIER FUNCTION, ASYMMETRIC DIMETHYLARGININE, APOLIPOPROTEIN M, HDL, ADMA, PROGRESSION, METABOLISM, MECHANISM, MELLITUS, ALBUMIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: Sphingosine 1-phosphate (S1P) is carried in plasma by the HDL particles and albumin. It mediates several protective functions of HDL. Because of its barrier-enhancing effect, it has attracted attention in diseases associated with endothelial dysfunction. We examined the impact of circulating levels of S1P in diabetic nephropathy together with apoprotein M, a S1P-binding protein in HDL. Plasma levels of dimethylarginines were evaluated in this context.