The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes

Bekpinar S., Yenidunya G., Gurdol F., Unlucerci Y., Aycan-Ustyol E., Dinccag N.

CLINICAL BIOCHEMISTRY, vol.48, pp.1264-1267, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 18
  • Publication Date: 2015
  • Doi Number: 10.1016/j.clinbiochem.2015.08.001
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.1264-1267


Objectives: Sphingosine 1-phosphate (S1P) is carried in plasma by the HDL particles and albumin. It mediates several protective functions of HDL. Because of its barrier-enhancing effect, it has attracted attention in diseases associated with endothelial dysfunction. We examined the impact of circulating levels of S1P in diabetic nephropathy together with apoprotein M, a S1P-binding protein in HDL. Plasma levels of dimethylarginines were evaluated in this context.