The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes

Bekpinar S., Yenidunya G., Gurdol F., Unlucerci Y., Aycan-Ustyol E., Dinccag N.

CLINICAL BIOCHEMISTRY, cilt.48, ss.1264-1267, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Objectives: Sphingosine 1-phosphate (S1P) is carried in plasma by the HDL particles and albumin. It mediates several protective functions of HDL. Because of its barrier-enhancing effect, it has attracted attention in diseases associated with endothelial dysfunction. We examined the impact of circulating levels of S1P in diabetic nephropathy together with apoprotein M, a S1P-binding protein in HDL. Plasma levels of dimethylarginines were evaluated in this context.