KCNJ11 polymorphisms and sudden cardiac death in patients with acute myocardial infarction


Jeron A., Hengstenberg C., Holmer S., Wollnik B., Riegger G., Schunkert H., ...Daha Fazla

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, cilt.36, ss.287-293, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 36 Konu: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.yjmcc.2003.11.009
  • Dergi Adı: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
  • Sayfa Sayıları: ss.287-293

Özet

Purpose. Patients with an acute myocardial infarction (AMI) are of high risk to develop ischemia-induced ventricular arrhythmias, leading to sudden cardiac death (SCD) in about one third of all AMI patients. The individual susceptibility to ischemia-induced arrhythmias may be modified by polymorphisms in genes encoding ion channels. The cardiac ATP-dependent potassium channel (K-ATP) current is generated by ion channels encoded by the KCNJ11 gene and the SUR2a gene. Opening of the K-ATP channel during ischemia results in action potential shortening in various studies and may therefore influence the outcome of AMI patients.