KCNJ11 polymorphisms and sudden cardiac death in patients with acute myocardial infarction

Jeron, A; Hengstenberg, C; Holmer, S; Wollnik, B; Riegger, GAJ; Schunkert, H; Erdmann, J

doi:10.1016/j.yjmcc.2003.11.009

KCNJ11 polymorphisms and sudden cardiac death in patients with acute myocardial infarction

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Jeron A., Hengstenberg C., Holmer S., Wollnik B., Riegger G., Schunkert H., ...More

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol.36, no.2, pp.287-293, 2004 (SCI-Expanded)

Publication Type: Article / Article
Volume: 36 Issue: 2
Publication Date: 2004
Doi Number: 10.1016/j.yjmcc.2003.11.009
Journal Name: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.287-293
Istanbul University Affiliated: No

Abstract

Purpose. Patients with an acute myocardial infarction (AMI) are of high risk to develop ischemia-induced ventricular arrhythmias, leading to sudden cardiac death (SCD) in about one third of all AMI patients. The individual susceptibility to ischemia-induced arrhythmias may be modified by polymorphisms in genes encoding ion channels. The cardiac ATP-dependent potassium channel (K-ATP) current is generated by ion channels encoded by the KCNJ11 gene and the SUR2a gene. Opening of the K-ATP channel during ischemia results in action potential shortening in various studies and may therefore influence the outcome of AMI patients.