The Current Status of Non-Biologic Liver Support in the Treatment of Liver Failure

Topaloglu S., Yankol Y., Kucukkartallar T., Ocak I., Dogruer K., Kocak B., ...Daha Fazla

JOURNAL OF MEDICAL AND SURGICAL INTENSIVE CARE MEDICINE, cilt.1, sa.1, ss.14-20, 2010 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 1 Sayı: 1
  • Basım Tarihi: 2010
  • Dergi Adı: JOURNAL OF MEDICAL AND SURGICAL INTENSIVE CARE MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE
  • Sayfa Sayıları: ss.14-20
  • Anahtar Kelimeler: Liver failure, non-biologic liver support systems, renal replacement therapy, ADSORBENT RECIRCULATING SYSTEM, RENAL REPLACEMENT THERAPY, PLASMA-EXCHANGE, ALBUMIN DIALYSIS, HEPATIC-FAILURE, FULMINANT, MANAGEMENT, HEMODIAFILTRATION, TRANSPLANTATION, PLASMAPHERESIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Hepatic failure is associated with high morbidity and mortality. Up to date, no realistic alternative to liver transplantation for permanent liver replacement has been developed. Liver support systems have been developed to support patients with borderline functional mass until their liver recovers or until a donor liver becomes available for transplantation. The major limitation to the provision of effective liver support is lack of a clear understanding of the pathophysiology of liver failure. In the current era, liver support systems are divided into biologic, non-biologic and bio-artificial (hybrid) liver support systems. In Turkey, as in other European countries, the non-biologic liver support systems are commonly preferred for liver support. We reviewed the operative principles, treatment algorithm, complications and current status of non-biologic liver support systems.