Use of Etests with carbapenems for Gram-negative rods producing beta-lactamases

Kocazeybek S., Arabaci U.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, cilt.19, ss.159-162, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Konu: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0924-8579(01)00487-3
  • Sayfa Sayıları: ss.159-162


The in vitro activity of imipenem and meropenem on strains of Gram-negative rods producing extended-spectrum beta-lactamase (ESBL) and inducible beta-lactamase (IBL) was studied using the Etest. In all, 185 strains from the surgical intensive care units of four different hospitals were looked at over 2 years. Of these, 94 were ESBL producers and 91 were IBL positive. The in vitro sensitivities of imipenem and meropenem were 89.7 and 95.1%, respectively, against all strains. The imipenem and meropenem sensitivities of Klebsiella spp. were 98.4 and 100%, respectively, but imipenem resistance (21.6%) in Pseudomonas aeruginosa strains was higher than that of meropenem (10.8%). (C) 2002 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.