Research Information System
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2026 (SCI-Expanded, Scopus)
Background Evaluation of long-term changes in the vitreoretinal interface in patients with retinopathy of prematurity (ROP) using ultrawide-field optical coherence tomography (OCT). This cross-sectional single-centre study included children with a history of ROP treated with either a single dose of intravitreal bevacizumab (IVB), laser photocoagulation (LPC), or those with spontaneous regression (SR).Methods Ultrawide-field OCT imaging was performed using an Optos Silverstone Swept Source-OCT device. Vitreoretinal abnormalities, including those in the former ridge area, vitreous veils, tractions, and adhesions, were grouped as 'vitreoretinal interface abnormalities'. The images were evaluated for these abnormalities.Results This study enrolled 188 eyes of 94 patients (76 eyes of 38 children, IVB group; 40 eyes of 28 children, LPC group; 72 eyes of 44 children, SR group). The prevalence of vitreoretinal interface abnormalities was 73.2% and 44.4% in the IVB and SR groups, respectively. All the patients in the LPC group showed abnormalities in laser and non-laser retinal areas.Conclusion Ultrawide-field OCT revealed various vitreoretinal interface abnormalities in patients with a history of ROP. Long-term follow-up and OCT evaluation of the peripheral retina, even without structural abnormalities on following examinations, may help prevent outcomes such as retinal detachment. Treatment of detected lesions remains uncertain.