The protective effects of <i>Myrtus communis</i> subsp. on ovariectomized diabetic rats' renal and intestinal tissues: <i>in vivo</i> and <i>in silico</i> approaches

Ertik O., Kadioglu-Yaman B., ŞEN A., ŞENER G., YANARDAĞ R.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol.131, no.2, pp.210-226, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 2
  • Publication Date: 2025
  • Doi Number: 10.1080/13813455.2024.2406895
  • Journal Name: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, MEDLINE
  • Page Numbers: pp.210-226
  • Istanbul University Affiliated: Yes

Abstract

IntroductionPostmenopausal diabetes is a condition that affects millions of women and their quality of life. Also, kidney and small intestine tissues are damaged due to diabetes. The present study aimed to examine the protective effects of an extract prepared from Myrtus communis leaves on kidney and small intestine tissues against experimentally created postmenopausal diabetes. MethodsFor this purpose, experimental rats were randomly divided into six groups (Control; ovariectomy:OVX, diabetic:D, ovariectomy + diabetic:OVX + D, ovariectomy + diabetic + oestrogen:OVX + D+E2, ovariectomy + diabetic + MC: OVX + D+MC) and kidney and small intestine tissues were taken after the experimental procedure. ResultsEvaluations of biochemical parameters (glutathione and glutathione-related enzymes, antioxidant enzymes, etc.) showed that MC had a protective effect on kidney and small intestine tissues in diabetes and ovariectomy groups. ConclusionIt can be suggested that MC extract has a protective effect on small intestine and kidney tissues in postmenopausal diabetes and may be a good herbal source for this purpose.