Differential expression of candidate circulating microRNAs in maternal blood leukocytes of the patients with preeclampsia and gestational diabetes mellitus

Hocaoğlu M., Demirer S., Senturk H., TURGUT A., Komurcu-Bayrak E.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, vol.17, pp.5-11, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2019
  • Doi Number: 10.1016/j.preghy.2019.04.004
  • Journal Name: PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5-11
  • Keywords: Preeclampsia, Gestational diabetes mellitus, microRNA, Maternal leukocytes, Biomarker, Diagnosis, NF-KAPPA-B, DIAGNOSTIC BIOMARKERS, PREGNANCY, MIR-21, PATHOGENESIS, MIGRATION, PROFILES, CELLS, RISK
  • Istanbul University Affiliated: Yes

Abstract

Objectives: Preeclampsia (PE) is diagnosed in women presenting with new onset hypertension accompanied by proteinuria. Gestational diabetes mellitus (GDM) is the carbohydrate intolerance that can occur in pregnancy. Neutrophil activation is related to PE and GDM. Circulating microRNAs (miRs) are small, noncoding RNA molecules. The aim of this study was to verify the expression levels of three candidate miRs in blood leukocytes of the patients with PE, GDM, and PE-GDM compared to healthy controls.