Differential expression of candidate circulating microRNAs in maternal blood leukocytes of the patients with preeclampsia and gestational diabetes mellitus

Hocaoğlu M., Demirer S., Senturk H., TURGUT A., Komurcu-Bayrak E.

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, cilt.17, ss.5-11, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.preghy.2019.04.004
  • Dergi Adı: PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5-11
  • Anahtar Kelimeler: Preeclampsia, Gestational diabetes mellitus, microRNA, Maternal leukocytes, Biomarker, Diagnosis, NF-KAPPA-B, DIAGNOSTIC BIOMARKERS, PREGNANCY, MIR-21, PATHOGENESIS, MIGRATION, PROFILES, CELLS, RISK
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: Preeclampsia (PE) is diagnosed in women presenting with new onset hypertension accompanied by proteinuria. Gestational diabetes mellitus (GDM) is the carbohydrate intolerance that can occur in pregnancy. Neutrophil activation is related to PE and GDM. Circulating microRNAs (miRs) are small, noncoding RNA molecules. The aim of this study was to verify the expression levels of three candidate miRs in blood leukocytes of the patients with PE, GDM, and PE-GDM compared to healthy controls.