Intraoperative Localization of Recurrent Medullary Carcinoma of the Thyroid Using Tc-99m HYNIC-TATE and a Surgical Gamma Probe

Aliyev A., Ocak M., Kabasakal L., Haciyev Y., Ozhan M., Vural O., ...More

CLINICAL NUCLEAR MEDICINE, vol.36, no.9, pp.831-833, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 36 Issue: 9
  • Publication Date: 2011
  • Doi Number: 10.1097/rlu.0b013e31821c9a36
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.831-833
  • Keywords: recurrent MTC, Tc-99m HYNIC-TATE, surgical gamma probe, NEUROENDOCRINE TUMORS, TC-99M-EDDA/HYNIC-TOC, SURGERY
  • Istanbul University Affiliated: Yes


Preoperative octreotide scintigraphy imaging has opened up a new era to approach recurrent medullary thyroid carcinoma (MTC). We describe the case of a 53-year-old woman who was diagnosed with recurrent MTC and elevated serum calcitonin level >2000 pg/mL. Preoperatively, Tc-99m HYNIC-TATE scintigraphy was used in identifying 2 focal abnormalities in the right upper cervical and left upper mediastinal regions, and a hand-held gamma probe was used intraoperatively to identify the hot areas. Six months after intraoperative dissection, serum calcitonin level and Tc-99m HYNIC-TATE scintigraphy were found normal. This case demonstrates the proper localization for recurrent MTC using Tc-99m HYNIC-TATE and a surgical gamma probe.