In-vitro activities of terbinafine, itraconazole and amphotericin B against Aspergillus and Cladosporium species


Kantarcioglu A., Yucel A.

JOURNAL OF CHEMOTHERAPY, cilt.14, ss.562-567, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 14 Konu: 6
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1179/joc.2002.14.6.562
  • Dergi Adı: JOURNAL OF CHEMOTHERAPY
  • Sayfa Sayıları: ss.562-567

Özet

The in vitro fungicidal and fungistatic activities of terbinafine were compared with those of itraconazole and amphotericin B against Aspergillus (n=63) and Cladosporium (n=21) isolates. The broth macrodilution modification of NCCLS reference method for filamentous fungi (M38-P) was used to assess the minimum inhibitory concentrations (MICs). Our data show that the in vitro activities of terbinafine were comparable to those of itraconazole and amphotericin B against the Aspergillus spp and Cladosporium strains tested. Despite strain-dependent variabilities, in general, itraconazole's activity was similar to that of amphotericin B against strains of Aspergillus and Cladosporium. Our data suggest that terbinafine may be useful in the treatment of Aspergillus and Cladosporium infections.