Utility of c-erbB-2 expression in tissue and sera of ovarian cancer patients

Yazici H., DOLAPCIOGLU K., BUYRU F., DALAY N.

CANCER INVESTIGATION, cilt.18, sa.2, ss.110-114, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.3109/07357900009038241
  • Dergi Adı: CANCER INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.110-114
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study expression of the c-erbB-2 gene in tumors and healthy tissue of patients with ovarian cancer was investigated. Serum c-erbB-2 protein levels were also determined. Elevated serum values were observed in 45% of patients. c-erbB-2 protein levels in the armors were significantly higher than in healthy tissue. Overexpression of the protein was observed in 60% of patients. However no association was found between the clinical variables and tumor c-erbB-2 expression. This is the first study in the literature investigating the c-erbB-2 oncoprotein levels in the normal and tumor tissue. We conclude that the role of the c-erbB-2 gene in ovarian cancer warrants further studies.