P15 peptide stimulates chondrogenic commitment and endochondral ossification

Zhang J., Eisenhauer P., Kaya O. A., Vaccaro A. R., Diallo C., Fertala A., ...Daha Fazla

INTERNATIONAL ORTHOPAEDICS, cilt.41, sa.7, ss.1413-1422, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s00264-017-3464-8
  • Dergi Adı: INTERNATIONAL ORTHOPAEDICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1413-1422
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose The synthetic 15 amino acid biomimetic peptide sequence (P15) derived from a region of the alpha (alpha)-1 chain of collagen I, has been shown to promote alpha 2 integrin activation and enhance intramembranous ossification. In this study, we ask if the P15 peptide also enhances bone formation through endochondral ossification, and determine if direct binding of alpha 2 integrin with P15 mediates integrin activation.