P15 peptide stimulates chondrogenic commitment and endochondral ossification


Zhang J., Eisenhauer P., Kaya O. A. , Vaccaro A. R. , Diallo C., Fertala A., ...More

INTERNATIONAL ORTHOPAEDICS, vol.41, no.7, pp.1413-1422, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 7
  • Publication Date: 2017
  • Doi Number: 10.1007/s00264-017-3464-8
  • Journal Name: INTERNATIONAL ORTHOPAEDICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1413-1422

Abstract

Purpose The synthetic 15 amino acid biomimetic peptide sequence (P15) derived from a region of the alpha (alpha)-1 chain of collagen I, has been shown to promote alpha 2 integrin activation and enhance intramembranous ossification. In this study, we ask if the P15 peptide also enhances bone formation through endochondral ossification, and determine if direct binding of alpha 2 integrin with P15 mediates integrin activation.