A genome screen for linkage disequilibrium in Turkish multiple sclerosis


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Eraksoy M.

Journal Of Neuroimmunology, vol.143, no.1, pp.129-132, 2003 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Volume: 143 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.3109/00207454.2013
  • Title of Journal : Journal Of Neuroimmunology
  • Page Numbers: pp.129-132

Abstract

A genome screen for linkage disequilibrium in Turkish multiple sclerosis

M. Eraksoya,*,1, A. Hensiekb,1, M. Kurtuncua,b, G. Akman-Demira, M. Kılıncc,

M. Gedizlioglud, B. Petek-Balcıe, O¨ . Anlarf, C. Kutlug, G. Saruhan-Direskenelih,

H.A. I˙drisoglua, E. Setakisi, A. Compstonb, S. Sawcerb

The Turkish Multiple Sclerosis Genetics Study Group (TMSGSG)

a Department of Neurology, Istanbul Faculty of Medicine, University of Istanbul, Capa, Istanbul TR-34390, Turkey

b Neurology Unit, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK

c Department of Neurology, Faculty of Medicine, University of Baskent, Ankara, Turkey

d Department of Neurology, Buca Social Security Hospital, I˙zmir, Turkey

e Department of Neurology, Haseki State Hospital, Istanbul, Turkey

f Department of Neurology, Faculty of Medicine, University of Yu¨zu¨ncu¨ yıl, Van, Turkey

g Department of Neurology, Faculty of Medicine, University of Osmangazi, Eskisehir, Turkey

h Neuroimmunology Laboratory, Department of Physiology, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey

iMRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK

Abstract

In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in

separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in EuropeanS

(GAMES) protocol. Twelve markers showing evidence for association were identified. One of these markers lying directly in a region which

is also implicated in the Turkish linkage screen (chromosome 5p15) and thus shows evidence for both linkage and association in independent

data sets.

D 2003 Elsevier B.V. All rights reserved.

Keywords: Multiple sclerosis; Turkey; Linkage disequilibrium; Genome screen

1. Introduction

Available epidemiological evidence indicates that several

genes determine susceptibility to multiple sclerosis with

each contributing only modest effect individually (Compston,

2000). In this complex situation, tests for association

are significantly more powerful than those based on linkage

and a genome-wide effort to find association by testing all

possible variants systematically would be the ideal experiment

(Collins et al., 1997; Risch and Merikangas, 1996).

Direct screening