A cyanobiphenyl–based fluorescent ''lighting–up'' sensor for highly selective and sensitive recognition of Al3+: Theoretical, practical and bioimaging studies


Guctekin Yasar O., Bostanci A., KARUK ELMAS Ş. N., Aydin D., Arslan F. N., Sadi G., ...More

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol.294, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 294
  • Publication Date: 2023
  • Doi Number: 10.1016/j.saa.2023.122556
  • Journal Name: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
  • Keywords: Aluminum, DFT, Fluorescent sensor, Food, Living cell
  • Istanbul University Affiliated: No

Abstract

The recognition of toxic Al3+ in foods and biosystems has of great interest to researchers. Herein, a novel cyanobiphenyl–based chemosensor CATH (E)-N'-((4′-cyano-4-hydroxy-[1,1′-biphenyl]-3-yl)methylene)thiophene-2-carbohydrazide was fabricated and shown to recognize Al3+ in HEPES buffer:EtOH (90:10, v:v, pH = 7.4) by ''lighting–up'' fluorescence sensing. The CATH evidenced high sensitivity (LOD = 13.1 nM) and excellent selectivity to Al3+ over competing cations. The Job's plot, TOF–MS and theoretical computation studies were performed to probe the binding mechanism of Al3+ to CATH. Additionally; CATH was successfully utilized to practical applications and employed to recover of Al3+ from different food samples. More importantly, it was employed to intracellular Al3+ detection in living cells including THLE2 and HepG2.