The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine

Kacar O., CEVATEMRE B., Hatipoglu I., Arda N., ULUKAYA E., YILMAZ V. T., ...More

BIOORGANIC & MEDICINAL CHEMISTRY, vol.25, no.6, pp.1770-1777, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1016/j.bmc.2017.01.033
  • Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1770-1777
  • Keywords: Cancer, Metal based anticancer agents, Palladium(II) complex, Cell cycle specific, Apoptosis, Cytotoxicity, Cell cycle arrest, IN-VITRO, SACCHARINATE COMPLEX, CHEMOTHERAPEUTIC-AGENTS, ANTICANCER THERAPY, CYTOTOXIC ACTIVITY, CISPLATIN, LINES, COMBINATION, MIMOSINE, PROTEIN
  • Istanbul University Affiliated: Yes

Abstract

Objectives: Palladium complexes are potent and less toxic molecules in comparison to other metal based agents. Here, we characterized two palladium(II) saccharinate complexes with terpyridine for their cell cycle specificity.