Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia

Kucur, Mine; ISMAN, Ferruh; BALCI, Can; Onal, Bülent; Hacibekiroglu, Munire; Ozkan, Ferda; OZKAN, Alper

doi:10.1016/j.urolonc.2007.07.020

Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia

Kucur M., ISMAN F. K., BALCI C., Onal B., Hacibekiroglu M., Ozkan F., ...More

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, vol.26, no.1, pp.47-52, 2008 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 26 Issue: 1
Publication Date: 2008
Doi Number: 10.1016/j.urolonc.2007.07.020
Journal Name: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.47-52
Istanbul University Affiliated: Yes

Abstract

Background: YKL-40, also called human cartilage glycoprotein-39 (HC gp-39) and chitotriosidase are homologs of family 18 glycosyl hydrolases secreted by human macrophages. Although high levels of YKL-40 and chitotriosidase are associated with several diseases, the physiological functions of these enzymes are still unclear. YKL-40, a growth factor for connective tissue cells, a migration factor for endothelial and vascular smooth muscle cells, is expressed by several types of solid human carcinoma, including prostate carcinoma.