Assoc. Prof. NİLÜFER BAYRAK

Publication Network

Articles 46

1. Aminated Quinolinequinones With EDG(s) as a Prostate Cancer Inhibitor: Mechanistic Insights and Pharmacokinetic Limitations

JANNUZZI A. T., Yilmaz A. M., Biswas A., Mondal S., Basavanakatti V. N., YILDIRIM H., et al.

Chemistry and Biodiversity , vol.23, no.1, 2026 (SCI-Expanded, Scopus) Sustainable Development

2. Targeting Cancer Cell Proliferation Using Piperazine-Linked Quinolinequinones: Mechanism and Metabolic Profile

YILMAZ GÖLER A. M., JANNUZZI A. T., Biswas A., Mondal S., Basavanakatti V. N., Yildirim H., et al.

CHEMICAL BIOLOGY & DRUG DESIGN , no.6, 2025 (SCI-Expanded)

3. Prospects for Prostate Cancer Chemotherapy: Cytotoxic Evaluation and Mechanistic Insights of Quinolinequinones with ADME/PK Profile

JANNUZZI A. T., YILMAZ GÖLER A. M., Biswas A., Mondal S., Basavanakatti V. N., YILDIRIM H., et al.

Biomedicines , vol.12, no.6, 2024 (SCI-Expanded)

4. Scaffold Hopping and Structural Modification of NSC 663284: Discovery of Potent (Non)Halogenated Aminobenzoquinones

BAYRAK N., SEVER B., Ciftci H., Otsuka M., Fujita M., TUYUN A. F.

BIOMEDICINES , vol.12, no.1, 2024 (SCI-Expanded)

5. Discovery of the Aminated Quinoxalines as Potential Active Molecules

Bener S., BAYRAK N., MATARACI KARA E., Yıldız M., SEVER B., Çiftçi H., et al.

Letters in Drug Design and Discovery , vol.21, no.15, pp.3285-3297, 2024 (SCI-Expanded)

6. Cytotoxic activity of quinolinequinones in cancer: In vitro studies, molecular docking, and ADME/PK profiling

JANNUZZI A. T., YILMAZ GÖLER A. M., Shilkar D., Mondal S., Basavanakatti V. N., Yildirim H., et al.

CHEMICAL BIOLOGY & DRUG DESIGN , vol.102, no.5, pp.1133-1154, 2023 (SCI-Expanded) Sustainable Development

7. Analysis of Quinolinequinone Analogs with Promising Cytotoxic Activity against Breast Cancer

YILMAZ GÖLER A. M., Tarbin Jannuzzi A. T., Biswas A., Mondal S., Basavanakatti V. N., Jayaprakash Venkatesan R., et al.

CHEMISTRY & BIODIVERSITY , vol.20, no.9, 2023 (SCI-Expanded) Sustainable Development

8. Design, synthesis, in vitro and in silico characterization of plastoquinone analogs containing piperidine moiety as antimicrobial agents

Yıldız M., YILDIRIM H., BAYRAK N., Çakmak S. M., MATARACI KARA E., ÖZBEK ÇELİK B., et al.

Journal of Molecular Structure , vol.1277, 2023 (SCI-Expanded)

9. Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects

Ciftci H., SEVER B., Kaya N., BAYRAK N., Yıldız M., YILDIRIM H., et al.

Molecules , vol.28, no.1, 2023 (SCI-Expanded)

10. Aminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, In Vitro Evaluation, and Putative Mode of Action

YILDIRIM H., Bayrak N., YILDIZ M., Matraci-Kara E., Korkmaz S., Shilkar D., et al.

ACS OMEGA , vol.7, no.46, pp.41915-41928, 2022 (SCI-Expanded)

11. Exploring the Relationships between Structure and Antimicrobial Potency of Quinolinequinones

Mataraci-Kara E., Bayrak N., YILDIZ M., YILDIRIM H., TuYuN A. F.

ANTIBIOTICS-BASEL , vol.11, no.10, 2022 (SCI-Expanded)

12. In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights

Ciftci H., Sever B., Bayrak N., Tateishi H., Otsuka M., Fujita M., et al.

PHARMACEUTICALS , vol.15, no.10, 2022 (SCI-Expanded)

13. Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies

Ciftci H., Sever B., Ayan E., Can M., DeMirci H., Otsuka M., et al.

PHARMACEUTICALS , vol.15, no.10, 2022 (SCI-Expanded) Sustainable Development

14. In Vitro and In Silico Study to Assess Toxic Mechanisms of Hybrid Molecules of Quinone-Benzocaine as Plastoquinone Analogues in Breast Cancer Cells

Goler A. M. Y., JANNUZZI A. T., Bayrak N., Yildiz M., Yildirim H., Otsuka M., et al.

ACS OMEGA , vol.7, no.34, pp.30250-30264, 2022 (SCI-Expanded) Sustainable Development

15. Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure-activity relationship, activity profile, mode of action, and molecular docking

YILDIRIM H., YILDIZ M., BAYRAK N., Mataraci-Kara E., Ozbek-Celik B., Otsuka M., et al.

RSC ADVANCES , vol.12, no.32, pp.20507-20518, 2022 (SCI-Expanded)

16. Exploring the Anticancer Effects of Brominated Plastoquinone Analogs with Promising Cytotoxic Activity in MCF-7 Breast Cancer Cells via Cell Cycle Arrest and Oxidative Stress Induction

JANNUZZI A. T., Goler A. M. Y., Bayrak N., Yildiz M., Yildirim H., Yilmaz B. K., et al.

PHARMACEUTICALS , vol.15, no.7, 2022 (SCI-Expanded) Sustainable Development

17. Highly Active Small Aminated Quinolinequinones against Drug-Resistant Staphylococcus aureus and Candida albicans

Yıldırım H., Bayrak N., Yıldız M., Yılmaz F. N., Mataracı-Kara E., Shilkar D., et al.

MOLECULES , vol.27, no.9, 2022 (SCI-Expanded)

18. Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking

Yıldırım H., Yıldız M., Bayrak N., Mataracı-Kara E., Radwan M. O., Jannuzzi A. T., et al.

PHARMACEUTICALS , vol.15, no.5, 2022 (SCI-Expanded) Sustainable Development

19. In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment

Ciftci H., Sever B., Ocak F., Bayrak N., YILDIZ M., YILDIRIM H., et al.

MOLECULES , vol.27, no.3, 2022 (SCI-Expanded)

20. Active Quinolinequinones against Methicillin-Resistant Staphylococcus spp

Mataraci-Kara E., Bayrak N., Yildiz M., Yildirim H., Tuyun A. F.

CHEMISTRY & BIODIVERSITY , vol.19, no.1, 2022 (SCI-Expanded)

21. Exploration of brominated Plastoquinone analogs: Discovery and structure-activity relationships of small antimicrobial lead molecules

YILDIZ M., BAYRAK N., YILDIRIM H., Mataraci-Kara E., Shilkar D., Jayaprakash V., et al.

BIOORGANIC CHEMISTRY , vol.116, 2021 (SCI-Expanded)

22. Anticancer agents based on Plastoquinone analogs with N-phenylpiperazine: Structure-activity relationship and mechanism of action in breast cancer cells

JANNUZZI A. T., Yildiz M., Bayrak N., Yildirim H., Shilkar D., Jayaprakash V., et al.

CHEMICO-BIOLOGICAL INTERACTIONS , vol.349, 2021 (SCI-Expanded) Sustainable Development

23. Bis(Substituted Phenylamino)Glyoxime derivatives: Synthesis, characterization, and antimicrobial evaluation

TUYUN A. F., BAYRAK N., YILDIRIM H., Yıldız M., MATARACI KARA E., ÖZBEK ÇELİK B.

JOURNAL OF MOLECULAR STRUCTURE , vol.1242, 2021 (SCI-Expanded)

24. Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs

Ciftci H., Bayrak N., Yildiz M., Yildirim H., Sever B., Tateishi H., et al.

BIOORGANIC CHEMISTRY , vol.114, 2021 (SCI-Expanded) Sustainable Development

25. Plastoquinone analogs: a potential antimicrobial lead structure intensely suppressing Staphylococcus epidermidis and Candida albicans growth

Mataracı Kara E., Bayrak N., Yıldırım H., Yıldız M., Ataman M., Özbek Çelik B., et al.

MEDICINAL CHEMISTRY RESEARCH , vol.30, no.9, pp.1728-1737, 2021 (SCI-Expanded)

26. Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs

BAYRAK N., Ciftci H. I., Yıldız M., YILDIRIM H., Sever B., Tateishi H., et al.

CHEMICO-BIOLOGICAL INTERACTIONS , vol.345, 2021 (SCI-Expanded) Sustainable Development

27. Novel plastoquinone analogs containing benzocaine and its analogs: structure-based design, synthesis, and structural characterization

Bayrak N., Yildiz M., Yildirim H., Mataraci-Kara E., TUYUN A. F.

RESEARCH ON CHEMICAL INTERMEDIATES , vol.47, no.5, pp.2125-2141, 2021 (SCI-Expanded)

28. Brominated plastoquinone analogs: Synthesis, structural characterization, and biological evaluation

Bayrak N., Yıldız M., Yıldırım H., Mataracı Kara E., Özbek Çelik B., Tuyun A. F.

JOURNAL OF MOLECULAR STRUCTURE , vol.1219, 2020 (SCI-Expanded)

29. Chlorinated plastoquinone analogs that inhibitStaphylococcus epidermidisandCandida albicansgrowth

Kara E., Bayrak N., Yıldırım H., Yıldız M., Celik B., Tuyun A. F.

FOLIA MICROBIOLOGICA , vol.65, no.5, pp.785-795, 2020 (SCI-Expanded) Sustainable Development

30. A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity

Bayrak N., Yıldırım H., Yıldız M., Radwan M. O., Otsuka M., Fujita M., et al.

CHEMICAL BIOLOGY & DRUG DESIGN , vol.95, no.3, pp.343-354, 2020 (SCI-Expanded)

31. Crystal Structures of 2-Chloro-3-((3-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione and 2-Chloro-3-((4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione

Yildirim H., Yildiz M., Bayrak N., Sahin M., Tuyun A. F.

CRYSTALLOGRAPHY REPORTS , vol.64, no.7, pp.1030-1033, 2019 (SCI-Expanded)

32. Discovery of a new family of heterocyclic amine linked plastoquinone analogs for antimicrobial evaluation

Tuyun A. F., Yildiz M., Bayrak N., Yildirim H., Kara E., Jannuzzi A. T., et al.

DRUG DEVELOPMENT RESEARCH , vol.80, no.8, pp.1098-1109, 2019 (SCI-Expanded)

33. Discovery and structure-activity relationship of plastoquinone analogs as anticancer agents against chronic myelogenous leukemia cells

Ciftci H. I., Bayrak N., Yıldırım H., Yıldız M., Radwan M. O., Otsuka M., et al.

ARCHIV DER PHARMAZIE , vol.352, no.12, 2019 (SCI-Expanded) Sustainable Development

34. Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents

Bayrak N., Yıldırım H., Yıldız M., Radwan M. O., Otsuka M., Fujita M., et al.

BIOORGANIC CHEMISTRY , vol.92, 2019 (SCI-Expanded) Sustainable Development

35. Thiolated plastoquinone analogs: Synthesis, characterization, and antimicrobial evaluation

Yildirim H., Bayrak N., Yildiz M., Kara E., Celik B., Tuyun A. F.

JOURNAL OF MOLECULAR STRUCTURE , vol.1195, pp.681-688, 2019 (SCI-Expanded)

36. Novel azanaphtoquinone compounds with aromatic amino moiety: Synthesis, structural characterization, and antimicrobial features

Bayrak N.

JOURNAL OF MOLECULAR STRUCTURE , vol.1195, pp.411-416, 2019 (SCI-Expanded)

37. Investigation of Antimicrobial, Antibiofilm, and Cytotoxic Effects of Straight-Chained Sulfanyl Members of Arylamino-1,4-naphthoquinones as Potential Antimicrobial Agents

MATARACI KARA E., JANUZZI A. T., BAYRAK N., YILDIRIM H., YILDIZ M., TUYUN A. F., et al.

European Journal of Biology , vol.78, no.2, pp.117-123, 2019 (Scopus) Sustainable Development

38. Crystal Structure of 2-(Hexyloxy)benzo[b]phenazine-6,11-dione

Yildiz M., BAYRAK N., YILDIRIM H., Sahin M., TUYUN A. F.

CRYSTALLOGRAPHY REPORTS , vol.63, no.6, pp.925-929, 2018 (SCI-Expanded)

39. A new family of azanaphthoquinones for antimicrobial evaluation

Bayrak N.

CHEMISTRY CENTRAL JOURNAL , vol.12, 2018 (SCI-Expanded)

40. CRYSTAL STRUCTURE OF 2-(3,5-DIMETHOXYPHENYLAMINO)-3-CHLORONAPHTHALENE-1,4-DIONE

Bayrak N., Yildiz M., Yildirim H., Sahin M., Tuyun A. F.

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA , vol.32, no.3, pp.603-608, 2018 (SCI-Expanded, Scopus)

41. Novel Straight-Chained Sulfanyl Members of Arylamino-1,4naphthoquinones: Synthesis and Characterization

BAYRAK N.

Journal of the Turkish Chemical Society, Section A:Turkish Journal of Chemistry , vol.4, pp.597-606, 2017 (Scopus)

42. 2,3-Disubstituted-1,4-naphthoquinones containing an arylamine with trifluoromethyl group: synthesis, biological evaluation, and computational study

Yildirim H., Bayrak N., Tuyun A. F., Kara E. M., Celik B. O., Gupta G. K.

RSC ADVANCES , vol.7, no.41, pp.25753-25764, 2017 (SCI-Expanded)

43. Synthesis, Computational Study, and Evaluation of In Vitro Antimicrobial, Antibiofilm, and Anticancer Activities of New Sulfanyl Aminonaphthoquinone Derivatives

Bayrak N., Yildirim H., Tuyun A. F., Kara E. M., Celik B. O., Gupta G. K., et al.

LETTERS IN DRUG DESIGN & DISCOVERY , vol.14, no.6, pp.647-661, 2017 (SCI-Expanded)

44. Synthesis, Biological, and Computational Study of Naphthoquinone Derivatives Containing Heteroatoms

Bayrak N., Yildirim H., Tuyun A. F., Kara E. M., Celik B. O., Gupta G. K.

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN , vol.38, no.6, pp.1211-1221, 2016 (SCI-Expanded)

45. Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds

Tuyun A. F., Bayrak N., Yildirim H., Onul N., Kara E. M., Celik B. O.

JOURNAL OF CHEMISTRY , vol.2015, 2015 (SCI-Expanded)

46. Spectroscopic and structural aspects of the reactions of 1,4-quinones with sulfur and nitrogen nucleophiles

Bayrak N., Tuyun A. F., Yildirim H., Onul N.

COMPTES RENDUS CHIMIE , vol.17, no.6, pp.563-569, 2014 (SCI-Expanded)

Papers Presented at Peer-Reviewed Scientific Conferences 37

1. New 3,4-dimethoxyphenyl substituted compounds as potential EGFR inhibitors

Reymova F., Atak B., Sever B., Topalan E., Sevimli Gür C., Can M., et al.

13th International Drug Chemistry Conference , Antalya, Turkey, 6 - 09 February 2025, pp.48, (Summary Text)

2. Artificial Intelligence-driven Discovery of Quinone Molecules for the Treatment of Colorectal Cancer

Demir G., Bayrak N., Tuyun A. F., Sever B., Otsuka M., Fujita M., et al.

5th Anatolian Conference on Organic Chemistry, Antalya, Turkey, 3 - 05 February 2025, pp.20, (Summary Text)

3. Synthesis and Evaluation of New Quinone-Based Heterocycles Against Tumor Cell Lines

Bayrak N., Tuyun A. F.

10th International Conference on New Trends in Chemistry, Budapest, Hungary, 19 - 21 April 2024, pp.47, (Summary Text)

4. Identification of Aminobenzoquinones As EGFR Inhibitors

Tuyun A. F., Bayrak N.

10th International Conference on New Trends in Chemistry , Budapest, Hungary, 19 - 21 April 2024, pp.48, (Summary Text)

5. Development of New 1,4-Benzoquinone Derivatives as EGFR-TK Inhibitors

Düzgün E., Bayrak N., Tuyun A. F., Sever B., Demirci H., Ciftci H.

9th International BAU Drug Design Congress , İstanbul, Turkey, 29 November - 02 December 2023, pp.11, (Summary Text)

6. Identification of Plastoquinone Analogs To Be Effective in Breast Cancer Treatment

Tuyun A. F., Bayrak N., Yıldız M., Yıldırım H., Jannuzzı A. T., Shilkar D., et al.

EFMC-ASMC International Symposium on Advances in Synthetic and Medicinal Chemistry, Zagreb, Croatia, 3 - 07 September 2023, pp.250, (Summary Text)

7. Sulfonamide-Based Azanaphthoquinone Hybrid Molecules: Promising Antimicrobial Agents

Tuyun A. F., Bayrak N.

EFMC-ASMC International Symposium on Advances in Synthetic and Medicinal Chemistry, Zagreb, Croatia, 3 - 07 September 2023, pp.149, (Summary Text)

8. New Isoquinolinequinone Analogs As Potential Anticancer Agents

Bayrak N., Tuyun A. F.

EFMC-ASMC International Symposium on Advances in Synthetic and Medicinal Chemistry, Zagreb, Croatia, 3 - 07 September 2023, pp.109, (Summary Text)

9. Synthesis of New Imidazole Substituted Chalcones with Antimicrobial Study

Mammadov E., Bayrak N., Mataracı Kara E., Tuyun A. F.

19th Asian Chemical Congress, İstanbul, Turkey, 9 - 14 July 2023, no.313, pp.102, (Summary Text)

10. Biologically Important Members of The Quinone Family: Abenquines and Their Analogs

Tuyun A. F., Bayrak N., Mataracı Kara E.

19th Asian Chemical Congress, İstanbul, Turkey, 9 - 14 July 2023, no.423, pp.105, (Summary Text)

11. Discovery of Isoquinolinequinones with Promising Biological Properties

Bayrak N., Mataracı Kara E., Tuyun A. F.

19th Asian Chemical Congress , İstanbul, Turkey, 9 - 14 July 2023, no.430, pp.107, (Summary Text)

12. Microwave-Assisted Synthesis of Alkoxy Substituted Chalcones

Kıraç Aydın A., Bayrak N., Mataracı Kara E., Tuyun A. F.

19th Asian Chemical Congress, İstanbul, Turkey, 9 - 14 July 2023, no.436, pp.108, (Summary Text)

13. Novel Abenquine Analogs: Synthesis and Biological Activity

Gafuroğlu V., Bayrak N., Mataracı Kara E., Tuyun A. F.

19th Asian Chemical Congress, İstanbul, Turkey, 9 - 14 July 2023, no.287, pp.106, (Summary Text)

14. Design, Synthesis, and Investigation of the Biological Properties of the Quinolinequinone Analogs

Taghiyeva A., Bayrak N., Mataracı Kara E., Tuyun A. F.

19th Asian Chemical Congress , İstanbul, Turkey, 9 - 14 July 2023, no.300, pp.108, (Summary Text)

15. "Alkoxy- and Thiosubstituted-1,4-Quinones"

Bayrak N., GÖKSEL F. S., İbiş C.

5th International Symposium on Pharmaceutical Chemistry, İstanbul, Turkey, pp.97, (Full Text)

16. Synthesis and Characterization of Novel Quinone Derivatives

Yıldız M., Tuyun A. F., Bayrak N., Yıldırım H., Mataracı Kara E., Özbek Çelik B.

4th Organic Chemistry Congress with International Participation, Antalya, Turkey, 4 - 07 October 2018, vol.PP59, pp.293, (Full Text)

17. Structure-activity Relationship Study of Azanaphthoquinones for Anticancer and Antimicrobial Evaluation

TUYUN A. F., BAYRAK N.

International Symposium on Multidisciplinary Studies (ISMS), Ankara, Turkey, 10 - 11 November 2017, pp.20, (Summary Text)

18. Nucleophilic Substitution Reactions of Dimethylbenzoquinones with Alkoxy Amines and Their Biological Evaluation

YILDIRIM H., TUYUN A. F., BAYRAK N., MATARACI KARA E., ÖZBEK ÇELİK B.

The Second Japan-Turkey International Symposium on Pharmaceutical and Biomedical Sciences, Trabzon, Turkey, 11 - 12 September 2017, pp.61, (Full Text)

19. Synthesis and Biological Evaluation of Dimethyl Amino Benzoquinones

BAYRAK N., TUYUN A. F., YILDIRIM H., MATARACI KARA E., ÖZBEK ÇELİK B.

The Second Japan-Turkey International Symposium on Pharmaceutical and Biomedical Sciences, Trabzon, Turkey, 11 - 12 September 2017, pp.63, (Full Text)

20. Antimicrobial and Anticancer Activities of Amino Sulfanyl 1,4-Naphthoquinone and Benzo[b]phenazine-6,11-dione Derivatives

TUYUN A. F., BAYRAK N., YILDIRIM H., MATARACI KARA E., ÖZBEK ÇELİK B., Nasiri H. R.

6th International Chemistry Conference, Riyad, Saudi Arabia, 8 - 10 November 2016, (Full Text)

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