Announcements & Documents
Education Information
1987 - 1993
1987 - 1993Doctorate
Istanbul University, Faculty Of Pharmacy , Farmasötik Kimya Anabilim Dalı, Turkey
1985 - 1987
1985 - 1987Postgraduate
Istanbul University, Faculty Of Pharmacy , Framasötik Kimya Anabilim Dalı, Turkey
1981 - 1985
1981 - 1985Undergraduate
Istanbul University, Faculty Of Pharmacy , Turkey
Dissertations
1993
1993Doctorate
Sübstitüe kinazolinonilmerkaptoasetik asid hidrazidlerinden kazanılan tiyosemikarbazidler ve tiyazolidonlar
Istanbul University, Faculty of Pharmacy , Farmasötik Kimya Anabilim Dalı
1987
1987Postgraduate
Kumarinil keton tiyosemikarbazonlar ve kumariniltiyazolon hidrazonlar üzerinde çalışmalar
Istanbul University, Faculty of Pharmacy , Farmasötik Kimya Anabilim Dalı
Foreign Languages
B2 Upper Intermediate
B2 Upper IntermediateEnglish
Certificates, Courses and Trainings
2024
2024ORPHEUS SÜRECİ VE DANIŞMANLIK EĞİTİMİ KURSU VI
Education Management and Planning
İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü
2023
2023İŞ SAĞLIĞI VE GÜVENLİĞİ EĞİTİMLERİ
Occupational Health and Safety
İş Sağlığı ve Güvenliği Koordinatörü- Prof. Dr. Halim İşsever
2023
2023ORPHEUS SÜRECİ VE DANIŞMANLIK EĞİTİMİ KURSU IV
Education Management and Planning
İstanbul Üniversitesi
2022
2022ORPHEUS SÜRECİ VE DANIŞMANLIK EĞİTİMİ KURSU III
Education Management and Planning
İstanbul Üniversitesi Sürekli Eğitim Uygulama ve Araştırma Merkezi
2022
2022KAMU ETİĞİ
Quality Management
İstanbul Üniversitesi Personel Daire Başkanlığı Hizmetiçi Eğitim Şube Müdürlüğü ve Açık ve Uzaktan Eğitim Fakültesi
2022
2022ETKİLİ İLETİŞİM KAVRAMI VE SÜRECİ
Personal Evolution
İstanbul Üniversitesi Personel Daire Başkanlığı Hizmetiçi Eğitim Şube Müdürlüğü ve Açık ve Uzaktan Eğitim Fakültesi
2021
2021ORPHEUS SÜRECİ VE DANIŞMANLIK EĞİTİMİ KURSU II
Education Management and Planning
İstanbul Üniversitesi Sürekli Eğitim Uygulama ve Araştırma Merkezi
2021
2021BEDEN DİLİ / KİNEZİK
Personal Evolution
İstanbul Üniversitesi Personel Daire Başkanlığı Hizmetiçi Eğitim Şube Müdürlüğü ve Açık ve Uzaktan Eğitim Fakültesi
2021
2021BİREY VE AİLELER İÇİN AFET BİLİNCİ
Security
İstanbul Üniversitesi Personel Daire Başkanlığı Hizmetiçi Eğitim Şube Müdürlüğü ve Açık ve Uzaktan Eğitim Fakültesi
2021
2021EMPATİ BECERİSİ VE EMPATİK İLETİŞİM
Personal Evolution
İstanbul Üniversitesi Personel Daire Başkanlığı Hizmetiçi Eğitim Şube Müdürlüğü ve Açık ve Uzaktan Eğitim Fakültesi
2021
2021ECZAK Değerlendirici Eğitimi
Quality Management
Eczacılık Eğitimi Programlarını Değerlendirme ve Akreditasyon Derneği (ECZAKDER)
2021
2021İş Sağlığı ve Güvenliği Eğitimi
Occupational Health and Safety
İş Sağlığı ve Güvenliği Koordinatörü- Prof. Dr. Halim İşsever
2018
2018Startejik Çevik Liderlik
Education Management and Planning
Pozitum Eğitim Danışmanlık
2017
2017DİZE ve ADİZE Eğitim Çalıştayı
Education Management and Planning
Eczacılık Eğitimi Programlarını Değerlendirme ve Akreditasyon Derneği (ECZAKDER)
2017
2017Aktif Öğrenme yöntemleri ve soru hazırlama kursu
Education Management and Planning
Kurumsal Eğitim Yönetimi ve Planlama Sistemi Eğitim Departmanı
2016
2016TÜBİTAK 1000 Projeleri AR-GE Strateji Çalıştayı
Education Management and Planning
İstanbul Üniversitesi Rektörlüğü
2016
2016Eğiticilerin Eğitimi
Education Management and Planning
Kurumsal Eğitim Yönetimi ve Planlama Sistemi Eğitim Departmanı
2015
2015İş Güvenliği
Occupational Health and Safety
İ.Ü.Sürekli Eğitim Uygulama Ve Araştırma Merkezi
2014
2014Eğitim Becerileri Kursu
Education Management and Planning
İstanbul Üniversitesi Rektörlüğü
2013
2013Ulusal Eczacılık Eğitimi Akreditasyon Kurulu
Quality Management
ECZAK
2012
2012Farmasötik Buluşlarda Patent, Ruhsatlandırma ve Hukuki Uygulamalar Sempozyumu
Education Management and Planning
Acıbadem Üniversitesi Sürekli Eğitim ve Geliştirme Merkezi
Research Areas
Health Sciences
Pharmacology and Therapeutics
Professional Sciences
Pharmaceutical Chemistry
Academic Titles / Tasks
2004 - Continues
2004 - ContinuesProfessor
Istanbul University, Faculty of Pharmacy , Department of Professional Pharmaceutical Sciences
1998 - 2004
1998 - 2004Associate Professor
Istanbul University, Faculty of Pharmacy , Department of Professional Pharmaceutical Sciences
Managerial Experience
2009 - Continues
2009 - ContinuesFakülte Yönetim Kurulu Üyesi
Istanbul University, Faculty Of Pharmacy , Department Of Professional Pharmaceutical Sciences
2019 - 2022
2019 - 2022Head of Department
Istanbul University, Faculty Of Pharmacy , Department Of Professional Pharmaceutical Sciences
2011 - 2021
2011 - 2021Fakülte Akademik Kurul Üyesi
Istanbul University, Faculty Of Pharmacy , Department Of Professional Pharmaceutical Sciences
2014 - 2016
2014 - 2016Head of Department
Istanbul University, Faculty Of Pharmacy , Department Of Professional Pharmaceutical Sciences
2007 - 2009
2007 - 2009BAP Scientific Commissioner
Istanbul University, Faculty Of Pharmacy , Department Of Professional Pharmaceutical Sciences
2003 - 2004
2003 - 2004Fakülte Yönetim Kurulu Üyesi
Istanbul University, Faculty Of Pharmacy , Department Of Professional Pharmaceutical Sciences
2000 - 2004
2000 - 2004Fakülte Kurulu Üyesi
Istanbul University, Faculty Of Pharmacy , Department Of Professional Pharmaceutical Sciences
Non Academic Experience
2017 - Continues
2017 - ContinuesKurul üyesi, proje değerlendirme ve izleme
KOSGEB
2015 - Continues
2015 - ContinuesYönetim Kurulu Üyesi
Ulusal Eczacılık Eğitimi Akreditasyon Kurulu (ECZAK)
2015 - 2023
2015 - 2023Yönetim Kurulu Üyesi
Professional Association, Eczacılık Eğitimi Programlarını Değerlendirme ve Akreditasyon Kurulu-ECZAK, Eczacılık Eğitimi Programlarını Değerlendirme ve Akreditasyon Kurulu-ECZAK
2012 - 2023
2012 - 2023Değerlendirme İzleme Ziyareti Ekibi (DİZE)
Professional Association, Eczacılık Eğitimi Programlarını Değerlendirme ve Akreditasyon Kurulu-ECZAK, Değerlendirme İzleme Ziyareti Ekibi (DİZE)
Courses
Advising Theses
2023
2023Postgraduate
Benzotiyazolin Artığı Taşıyan Spiroindolinonlar; Sentez, Yapı Tayini ve Biyolojik Etki Araştırmaları
Karalı N. L. (Advisor)
N.Karabağ(Student)
2019
2019Doctorate
İnterlökin-1 inhibitörü ilaç adayı yeni 5-(triflorometoksi)-1H-indol-2,3-dion 3-(4-feniltiyosemikarbazon) türevlerinin tasarımı, sentezi ve etkinliklerinin incelenmesi
KARALI N. L.
Ö.Soylu(Student)
2018
2018Doctorate
1-Sübstitüe 5-floro-1H-2-indolinon türevlerinin sentezi ve biyolojik etkilerinin incelenmesi
KARALI N. L.
Z.Şeyma(Student)
2017
2017Doctorate
3-Sülfamoilfenil Artığı Taşıyan 1H-İndol-2,3-Dion 3-Tiyosemikarbazon Türevleri: Sentez, Yapı Tayini, Moleküler Modelleme ve Biyolojik Aktivite Tayini
KARALI N. L.
P.Eraslan(Student)
2010
2010Postgraduate
5-Klorobenzotiyazolin artığı taşıyan spiroindolinonların sentezi ve antioksidan etkilerinin incelenmesi
KARALI N. L.
G.Ermut(Student)
Published journal articles indexed by SCI, SSCI, and AHCI
2024
2024Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors
Soylu-Eter O., Ozsoy N., KARALI N. L.
FUTURE MEDICINAL CHEMISTRY , 2024 (SCI-Expanded)
2024
20241H-Indole-2,3-dione 3-thiosemicarbazones carrying a 4-sulfamoylphenyl moiety with selective antiviral activity against Reovirus-1
Soylu-Eter Ö., Göktaş F., Duran G. N., Özbil M., Karalı N. L.
ACTA CHIMICA SLOVENICA , vol.71, no.2, pp.215-225, 2024 (SCI-Expanded)
2024
2024Exploring data-driven chemical SMILES tokenization approaches to identify key protein–ligand binding moieties
Temizer A. B., Uludoğan G., Özçelik R., Koulani T., Ozkirimli E., Ulgen K. O., et al.
Molecular Informatics , vol.43, no.3, 2024 (SCI-Expanded)
2024
2024Novel 2-indolinone derivatives as promising agents against respiratory syncytial and yellow fever viruses
APAYDIN Ç. B., Goektas F., Naesens L., KARALI N. L.
FUTURE MEDICINAL CHEMISTRY , 2024 (SCI-Expanded)
2024
2024A Mini-Review on the Synthesis of Substituted Isatins: From Early Approaches to Recent Advances with a Specific Focus on Sulfamoyl and Amino Derivatives
Temizer A. B., Koulani T., Eter O. S., KARALI N. L.
MINI-REVIEWS IN ORGANIC CHEMISTRY , no.1, pp.58-72, 2024 (SCI-Expanded)
2023
20235-Fluoro/(trifluoromethoxy)-2-indolinone derivatives with anti-interleukin-1 activity
Soylu-Eter Ö., Sevinçli Z. Ş., Ersoy B., Hasanusta B., Gatfar U., Lack N. A., et al.
Archiv der Pharmazie , vol.356, no.12, 2023 (SCI-Expanded)
2023
2023Antiviral activity and molecular modeling studies on 1H-indole-2,3-diones carrying a naphthalene moiety
SOYLU ETER Ö., Duran G. N., Özbil M., GÖKTAŞ F., CİHAN ÜSTÜNDAĞ G., KARALI N. L.
JOURNAL OF MOLECULAR STRUCTURE , vol.1281, 2023 (SCI-Expanded)
2023
2023Bioisosterism: 1,2,4-Oxadiazole Rings
CAMCI M., KARALI N. L.
ChemMedChem , vol.18, no.9, 2023 (SCI-Expanded)
2022
2022Synthesis and molecular modeling studies of 1-benzyl-2-indolinones as selective AChE inhibitors
Apaydın Ç. B., Soylu Eter Ö., Eraslan-Elma P., Özsoy N., Karall N. L.
Future Medicinal Chemistry , vol.14, no.23, pp.1705-1723, 2022 (SCI-Expanded)
2022
2022Exploiting pretrained biochemical language models for targeted drug design
Uludogan G., Ozkirimli E., Ulgen K. O., Karal N. L., Ozgur A.
BIOINFORMATICS , vol.38, 2022 (SCI-Expanded)
2022
2022New 1H-indole-2,3-dione 3-thiosemicarbazones with 3-sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors.
Eraslan-Elma P., Akdemir A., Berrino E., Bozdağ M., Supuran C. T., Karalı N. L.
Archiv der Pharmazie , vol.355, 2022 (SCI-Expanded)
2022
2022Selective Cytotoxic Effects of 5-Trifluoromethoxy-1H-indole-2,3-dione 3-Thiosemi-carbazone Derivatives on Lymphoid-originated Cells
Danışman-Kalındemirtaş F., Erdem-Kuruca S., Akgün-Dar K., Karakaş Z., Soylu Ö., Karali N. L.
Anti-Cancer Agents in Medicinal Chemistry , vol.22, no.2, pp.349-355, 2022 (SCI-Expanded)
2021
2021Synthesis, molecular modelling and cholinesterase inhibitory effects of 2-indolinone based hydrazinecarbothioamides
Demir Yazıcı K., Apaydın Ç. B., Soylu Eter Ö., Özsoy N., Karalı N. L.
FUTURE MEDICINAL CHEMISTRY , vol.13, pp.2133-2151, 2021 (SCI-Expanded)
2020
2020Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones
Sevinçli Z. Ş., Karalı N. L.
BIOORGANIC CHEMISTRY , vol.104, pp.104202, 2020 (SCI-Expanded)
2019
2019Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida beta-carbonic anhydrase enzyme
AKDEMİR A., Angeli A., Goektas F., Eraslan Elma P., Karali N. L., Supuran C. T.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.34, no.1, pp.528-531, 2019 (SCI-Expanded)
2017
2017Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases
Karali N., AKDEMİR A., Goktas F., Elma P. E., Angeli A., Kizilirmak M., et al.
BIOORGANIC & MEDICINAL CHEMISTRY , vol.25, no.14, pp.3714-3718, 2017 (SCI-Expanded)
2016
2016Isatin analogs as novel inhibitors of Candida spp. beta-carbonic anhydrase enzymes
Akdemir A., Guzel-Akdemir O., Karali N. L., Supuran C. T.
BIOORGANIC & MEDICINAL CHEMISTRY , vol.24, no.8, pp.1648-1652, 2016 (SCI-Expanded)
2015
2015Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII
Guzel-Akdemir O., AKDEMİR A., Karali N., Supuran C. T.
ORGANIC & BIOMOLECULAR CHEMISTRY , vol.13, no.23, pp.6493-6499, 2015 (SCI-Expanded)
2015
2015The intramolecular hydrogen bond analysis in biologically active 5-fluoro-1h-indole-2,3-dione-3-thiosemicarbazones derivatives by experimental and theoretical methods
KARAYEL A., Kayanak F. B., Karali N. L., ÖZBEY S.
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES , vol.71, 2015 (SCI-Expanded)
2014
2014New spiroindolinones bearing 5-chlorobenzothiazole moiety
Ermut G., Karali N. L., Ozsoy N., Can A.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.29, pp.457-468, 2014 (SCI-Expanded)
2013
2013Three novel compounds of 5-trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone: Synthesis, crystal structures and molecular interactions
KAYNAK F. B., ÖZBEY S., Karali N. L.
JOURNAL OF MOLECULAR STRUCTURE , vol.1049, pp.157-164, 2013 (SCI-Expanded)
2010
2010Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents
Karali N., Guzel O., Ozsoy N., Özbey S., Salman A.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.45, pp.1068-1077, 2010 (SCI-Expanded)
2010
20105-Chlorobenzothiazole-2-spiro-3 '-indolin-2 '-one
AKKURT M., Karaca S., Ermut G., Karali N., Buyukgungor O.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE , vol.66, 2010 (SCI-Expanded)
2008
2008Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives
Guzel O., Karali N., Salman A.
BIOORGANIC & MEDICINAL CHEMISTRY , vol.16, no.19, pp.8976-8987, 2008 (SCI-Expanded)
2007
2007Synthesis and structure-antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Karali N. L., Guersoy A., Kandemirli F., Shvets N., Kaynak F. B., Oezbey S., et al.
BIOORGANIC & MEDICINAL CHEMISTRY , vol.15, no.17, pp.5888-5904, 2007 (SCI-Expanded)
2006
2006Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives
Terzioğlu N., Karali N. L., Gürsoy A., Pannecouque C., Leysen P., Paeshuyse J., et al.
ARKIVOC , pp.109-118, 2006 (SCI-Expanded)
2006
2006C - H center dot center dot center dot F, N / C - H center dot center dot center dot S and C - H center dot center dot center dot pi interactions in 5-fluoro-1H-indole-2,3-dione-3-thiosemicarbazones
ÖZBEY S., KAYNAK F. B., Eriksson L., Karali N. L., Gursoy A.
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES , vol.62, 2006 (SCI-Expanded)
2005
2005Synthesis, characterization and primary antimicrobial activity evaluation of 3-phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic acid arylidenehydrazides
Gürsoy A., Ünal B., Karalı N. L., Ötük G.
Turkish Journal Of Chemistry , vol.29, pp.233-245, 2005 (SCI-Expanded)
2004
2004Synthesis and antimicrobial activity of some benzazole derivatives
Karalı N. L., Cesur N., Gürsoy A., Ateş Ö.
Indian Journal Of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry , vol.43, no.1, pp.212-216, 2004 (SCI-Expanded)
2003
2003Synthesis and primary cytotoxicity evaluation of 3-[[(3-phenyl-4(3H)quinazolinone-2-yl)mercaptoacetyl] hydrazono]-1H-2-indolinones
Gursoy A., Karali N. L.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.38, pp.633-643, 2003 (SCI-Expanded)
2003
2003Synthesis of 4-(3-coumarinyl)-3-benzyl-4-thiazolin-2-one 4-methylbenzylidenehydrazone and determination of the isomeric structure by X-ray analysis
Ozbey S., Karali N. L., Gurosy A.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE , vol.218, no.12, pp.819-822, 2003 (SCI-Expanded)
2003
2003Synthesis, characterization and primary antituberculosis activity evaluation of 4-(3-coumarinyl)-3-benzyl-4-thiazolin-2-one benzylidenehydrazones
Gürsoy A., Karalı N. L.
Turkish Journal Of Chemistry , vol.27, pp.545-551, 2003 (SCI-Expanded)
2002
2002Synthesis and primary cytotoxicity evaluation of new 5-nitroindole-2,3-dione derivatives
Karali N. L.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.37, no.11, pp.909-918, 2002 (SCI-Expanded)
2002
2002Synthesis and primary cytotoxicity evaluation of new 5-bromo-3-substituted-hydrazono-1H-2-indolinones.
Karali N. L., Terzioglu N., Gursoy A.
Archiv der Pharmazie , vol.335, no.8, pp.374-80, 2002 (SCI-Expanded)
2002
2002Synthesis and antitubercular activity of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazolin-2-one benzylidenehydrazones
Karali N. L., Kocabalkanli A., Gursoy A., Ates O.
FARMACO , vol.57, no.7, pp.589-593, 2002 (SCI-Expanded)
2000
20004-(3-Coumarinyl)-4-thiazolin-2-one benzylidenehydrazones with antituberculosis activity
Gursoy A., Karali N. L.
Arzneimittel-Forschung/Drug Research , vol.50, no.2, pp.167-172, 2000 (SCI-Expanded)
1999
1999Synthesis and pharmacology of new dithiocarbamic acid esters derived from phenothiazine and diphenylamine.
Karali N. L., Apak I., Ozkirimli S., Gursoy A., Dogan S., Eraslan A., et al.
Archiv der Pharmazie , vol.332, no.12, pp.422-6, 1999 (SCI-Expanded)
1998
1998New cyclohexylidenehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of 3-phenyl-4(3H)-quinazolinones
Karali N., Ilhan E., Gursoy A., Kiraz M.
FARMACO , vol.53, no.5, pp.346-349, 1998 (SCI-Expanded)
1998
1998Synthesis and structure-activity relationships of 3-hydrazono-1H-2-indolinones with antituberculosis activity
Karalı N. L., Gürsoy A.
Arzneimittel-Forschung-Drug Research , vol.48, pp.758-763, 1998 (SCI-Expanded)
1998
1998Simultaneous determination of medazepam and hyoscine butylbromide in tablets by second-derivative ultraviolet spectrometry
Karali N. L., Ozkirimli S., Gursoy A.
FARMACO , vol.53, no.1, pp.62-64, 1998 (SCI-Expanded)
1998
1998Synthesis and preliminary CNS depressant activity evaluation of new 3-[(3-substituted-5-methyl-4-thiazolidinon-2-ylidene)hydrazono]-1H-2-indolinones and 3-[(2-thioxo-3-substituted-4,5-imidazolidinedion-1-yl)imino]-1H-2-indolinones
Karalı N. L., Gürsoy A., Terzioğlu N., Özkırımlı S., Özer H., Ekinci A., et al.
Archiv Der Pharmazie , vol.331, pp.254-258, 1998 (SCI-Expanded)
1996
1996Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants
Gürsoy A., Karali N. L., Büyüktimkin S., Demirayak Ş., Ekinci A., Özer H.
FARMACO , vol.51, no.6, pp.437-442, 1996 (SCI-Expanded)
1996
1996Synthesis and antifungal activity of new carbamodithioic acid esters derived from 3-acetylcoumarin
Gursoy A., Ates O., Karali N. L., Cesur N., Kiraz M.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.31, pp.643-646, 1996 (SCI-Expanded)
1995
1995Synthesis and anticonvulsant activity of new acylthiosemicarbazides and thiazolidones
Karalı N. L., Gürsoy A.
FARMACO , vol.50, no.12, pp.857-866, 1995 (AHCI)
1994
1994Synthesis and anticonvulsant activity of some new thiosemicarbazone and 4-thiazolidone derivatives bearing an isatin moiety.
Karali N., Gürsoy A.
Farmaco (Societa chimica italiana : 1989) , vol.49, no.12, pp.819-22, 1994 (SCI-Expanded)
Articles Published in Other Journals
2021
2021Anti-proliferative effects of indomethacin, acemetacin and their tromethamine salts in HCT116 human colon cancer cells
Cihan Üstündağ G., Somuncu B., Müftüoğlu M., Karalı N. L.
Istanbul Journal of Pharmacy , vol.51, no.2, pp.161-166, 2021 (ESCI)
2021
2021Histone deacetylase inhibitors providing an epigenetic treatment in cancer
Cinek T., Karalı N. L.
Istanbul Journal of Pharmacy , vol.51, no.2, pp.283-290, 2021 (ESCI)
2021
2021Molecular and crystal structure of 1-methyl-5-trifluoromethoxy-1H-indole-2,3-dione 3-[4-(4-methoxyphenyl)thiosemicarbazone]
Eter O. S., Atioglu Z., Akkurt M., Ersanli C. C., Karalı N. L.
ISTANBUL JOURNAL OF PHARMACY , vol.51, no.1, pp.59-66, 2021 (ESCI)
2021
2021Anti-cytokine Targeted Approaches in COVID-19 Treatment
Camcı M., Karalı N. L.
Literatür Eczacılık Bilimleri Dergisi , vol.10, no.1, pp.29-37, 2021 (Peer-Reviewed Journal)
2020
2020Anticancer and antituberculosis effects of 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones
Sevinçli Z. Ş., Canturk Z., Dikmen M., Karalı N. L.
ISTANBUL JOURNAL OF PHARMACY , vol.50, no.3, pp.176-180, 2020 (ESCI)
2018
2018Anticancer activities and cell death mechanisms of 1H-indole-2,3-dione 3-[N-(4 sulfamoylphenyl)thiosemicarbazone] derivatives
Cetin I., Elma P. E., Topcull M. R., Karali N. L.
ISTANBUL JOURNAL OF PHARMACY , vol.48, pp.63-67, 2018 (ESCI)
2017
2017(2Z)-2-(5-Fluoro-1-methyl-2-oxoindolin-3-ylidene)-N-(3-fluorophenyl)hydrazine-1-carbothioamide
Atıoğlu Z., Sevinçli Z. Ş., Karalı N. L., Akkurt M., Ersanlı C.
IUCR DATA , vol.2, pp.1-3, 2017 (Peer-Reviewed Journal)
2017
20172-(5-Fluoro-1-methyl-2-oxoindolin-3-ylidene)-N-[4-(methylsulfanyl)phenyl]hydrazine-1-carbothioamide
Atıoğlu Z., Sevinçli Z. Ş., Karalı N. L., Akkurt M., Ersanlı C. C.
IUCR DATA , vol.2, pp.1-3, 2017 (Peer-Reviewed Journal)
2017
2017AlzheimerHastalığıveTedavisinde GüncelYaklaşımlar
Soylu Ö., Karalı N. L.
Literatür Eczacılık Bilimleri Dergisi , vol.6, no.2, pp.94-109, 2017 (Peer-Reviewed Journal)
2017
2017Antioxidant and cytotoxic properties of novel spirocyclic benzothiazolines
Cihan-Ustundag G., Ozsoy N., Oztas E., Karali N. L., Capan G.
MARMARA PHARMACEUTICAL JOURNAL , vol.21, no.4, pp.978-986, 2017 (ESCI)
2013
2013Antimicrobial and antiviral activity of spiroindolinones bearing benzothiazolines moiety
Güzel Ö., Karalı N. L., Ermut G., Birteksöz Tan A. S.
ISTANBUL JOURNAL OF PHARMACY , vol.43, no.1, pp.1-11, 2013 (ESCI)
2013
2013Synthesis and chemotherapeutic activities of 5-chloro-1H-indole-2,3-dione 3-thiosemicarbazones
Ermut G., KARALI N. L., ÇETİN İ., TOPÇUL M. R., Birteksoz S.
MARMARA PHARMACEUTICAL JOURNAL , vol.17, no.2, pp.147-154, 2013 (ESCI)
2013
2013ANTIMICROBIAL AND ANTIVIRAL ACTIVITY OF SPIROINDOLINONES BEARING BENZOTHIAZOLE MOIETY
Akdemir O. G., KARALI N. L., Ermut G., Tan A. S. B.
ISTANBUL JOURNAL OF PHARMACY , vol.43, no.1, pp.1-11, 2013 (ESCI)
2007
20075-Nitro-1H-indol-2,3-dion-3-(N-Feniltiyosemikarbazon)molekülünün infrared spektroskopisi ve teorik incelemesi
Sağnıç S., Kandemirli F., KARALI N. L., Dimoglo A. S.
BAÜ FBE Dergisi , vol.9, no.2, pp.3-16, 2007 (Peer-Reviewed Journal)
2006
2006Acute toxicity studies of two potential anticonvulsant 3-hydrazono-1H-2-indolinone derivatives
Aladağ İ., Özdemir O., Karalı N. L.
Journal of Faculty of Pharmacy of Istanbul University , vol.38, no.1, pp.65-70, 2006 (Peer-Reviewed Journal)
1998
1998New 4-thiazoline-2-hydrazono-1H-2-indolinones as possible antimicrobial agents.
Karali N., Terzioglu N., Gürsoy A., Otük G., Kiraz M., Yegenoglu Y.
Bollettino chimico farmaceutico , vol.137, pp.63-8, 1998 (Scopus)
1998
1998Synthesis and antimicrobial activity of new triazole and thiadiazole derivatives of 4(3H)-quinazolinones
Terzioğlu N., Karalı N. L., Gürsoy A., Ötük G., Kiraz M.
Acta Pharm. Turc. , vol.40, pp.77-82, 1998 (Peer-Reviewed Journal)
1997
1997Synthesis, characterization and preliminary anticonvulsant evaluation of new indoline-2,3-dione derivatives
Karalı N. L., Çapan G., Ergenç N., Gürsoy A.
Sciencia Pharmaceutica , vol.65, pp.277-287, 1997 (Scopus)
1992
1992Synthesis and characterisation of some 3-acetylcoumarin derivatives and their antimicrobial evaluation
Gürsoy A., Karalı N. L., Ötük G.
Acta Pharmaceutica Turcica , vol.34, pp.9-15, 1992 (Peer-Reviewed Journal)
Refereed Congress / Symposium Publications in Proceedings
2024
2024Synthesis and anticancer activities of 5-nonsubstituted/methyl-2-indolinone derivatives
Cinek T., Cihan Üstündağ G., Sancar Baş S., Özen Eroğlu G., Yıldırım M., Genç Akar Ö., et al.
12th International Drug Chemistry Congress, Antalya, Turkey, 7 - 10 March 2024, pp.42-46
2021
2021İstanbul Üniversitesi Eczacılık Fakültesi Farmasötik Kimya Anabilim Dalı Lisans ve Lisansüstü Öğrencilerinin Araştırma Çalışmaları
Karalı N. L.
III. ECZACILIK EĞİTİMİ VE AKREDİTASYON KONGRESİ, İstanbul, Turkey, 17 - 19 November 2021
2019
2019Molecular modelling and antiviral activity of 1H-indole-2,3-dione derivatives carrying naphthalene moiety
SOYLU Ö., Duran G. N., Özbil M., GÖKTAŞ F., CİHAN ÜSTÜNDAĞ G., Naesens L., et al.
7th International BAU Drug Design Congress, İstanbul, Turkey, 19 - 21 December 2019, pp.100-103
2019
2019Antiviral Bileşiklerin Herpes simplexs Virüslerine Bağlanmalarının in silico Analizi
Özbil M., Duran G. N., Sevinçli Z. Ş., KARALI N. L.
31. Ulusal Kimya Kongresi, İstanbul, Turkey, 10 - 13 September 2019, pp.159
2018
2018Development of novel compounds as Chemotherapeutic Drugs Targeting the MDM2-p53 Interaction
Gezen M., Taşkıran H., Tolay N., KARALI N. L., Erman B., Erman B.
Molbiyokon’18, Biomedicine and Genome Center, İzmir, Turkey, 5 - 08 September 2018, pp.62
2018
2018Identification of Novel Small Molecule Ligands Targeting Interleukin-1 Receptor by SPR-based Screening
Çetin R., SOYLU Ö., Sevinçli Z. Ş., KARALI N. L., Erman B., Orer H., et al.
6th International Congress of the Molecular Biology Association of Turkey, İzmir, Turkey, 5 - 08 September 2018, pp.117
2017
2017Molecular modelling studies to guide sythesis programs of new thiourea compounds as putative inhibitors of hCA IX/XII and VcCA
KARALI N. L.
3rd Satellite Meeting on Carbonic Anhydrase '' New Trends in Carbonic Anhydrases Research'', Montecatini Terme, Italy, 24 - 27 May 2017, pp.62
2017
2017Alzheimer hastalığı ve tedavisinde güncel yaklaşımlar
SOYLU Ö., KARALI N. L.
3. Uluslararası İlaç ve Eczacılık Kongresi, İstanbul, Turkey, 26 - 29 April 2017, pp.867
2017
2017Synthesis and crystal structure of (3Z)5-fluoro-1-methyl-1Hindole-2,3-dione 3-[4-(methylthio)phenyl] thiosemicarbazone
Atioğlu Z., Akkurt M., Sevinçli Z. Ş., KARALI N. L., Ersanlı C. C.
3.İlaç ve Eczacılık Kongresi, İstanbul, Turkey, 26 - 29 April 2017, pp.868-869
2017
2017Synthesis, biological evaluation and docking studies of structurally novel 1H-indole-2,3-dion 3-(N-phenylthiosemicarbazones) as potential hCA IX and XII inhibitors
ERASLAN ELMA P., Akdemir A., GÖKTAŞ F., KARALI N. L., Angeli A., Kızılırmak M., et al.
3.İlaç ve Eczacılık Kongresi, İstanbul, Turkey, 26 - 29 April 2017, pp.869
2016
20161H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazone] derivatives as putative anticancer and antifungal agents
Akdemir A., KARALI N. L., Supuran C. T., GÜZEL AKDEMİR Ö.
7th European Congress of Pharmacology EPHAR 2016, İstanbul, Turkey, 27 - 30 June 2016, pp.1
2015
2015The intramoleculer hydrogen bond analysis in biologically active 5-fluoro-1H-indole-2,3-dione-3-thiosemicarbazones derivatives by experimental and theoretical methods
Karayel A., Kaynak B., KARALI N. L., Özbey S.
29th European Crystallographic Meeting, Rovinj, Croatia, 23 - 28 August 2015, pp.468
2014
2014Synthesis and anticonvulsant activity of some new thiosemicarbazone and 4-thiazolidone derivatives bearing an isatin moiety
Gürsoy A., KARALI N. L.
First International Meeting on Pharmacy and Pharmaceutical Sciences, İstanbul, Turkey, 04 September 2014 - 07 September 1994, pp.175
2013
20135-Nitro-1H-indole-2,3-dione 3-[N4-(2/4-methoxyphenyl) thiosemicarbazone] derivatives
ERMUT G., KARALI N. L.
Challenges in Organic & Bioorganic Chemistry: 14th Tetrahedron Symposium, Viyana, Austria, 25 - 28 July 2013, pp.65
2013
2013Synthesis and biological evaluation of 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazone] derivatives as anticancer and antiviral agents
KARALI N. L., Kızılırmak M., ÇETİN İ., TOPÇUL M. R.
Challenges in Organic & Bioorganic Chemistry, 14th Tetrahedron Symposium, Viyana, Austria, 25 - 28 June 2013, pp.79
2012
20125-Klorobenzotiyazolin Artığı Taşıyan Spiroindolinonların Sentezi ve Antioksidan Etkilerinin İncelenmesi
ERMUT G., KARALI N. L.
III. Ulusal Farmasötik Kimya Kongresi, Malatya, Turkey, 1 - 04 September 2012, pp.6
2012
2012Synthesis, Characterization, Antiviral and Anticancer Activities Evaluation of New 1-Methyl-1H-indole-2,3-dione 3-[N-(4-sulfamoil)phenyl]thiosemicarbazone Derivatives, , Lefkoşa, Kıbrıs, 15-16 Haziran 2012.
Eraslan P., KARALI N. L.
Uluslararası Eczacılık Mezuniyet Projeleri Sempozyumu, Lefkoşa, Cyprus (Kktc), 15 - 16 June 2012, pp.1
2010
2010Antioxidant activity of spiroindolinones incorporating a 5-chlorobenzothiazoline moiety
ERMUT G., ÖZSOY N., KARALI N. L., CAN A.
IMPPS-3 Third International Meeting on Pharmacy & Pharmaceutical Sciences, ISTANBUL, Turkey, 1 - 04 June 2010, pp.116
2010
20105-triflorometoksi-1H-İndol-2,3-Dion 3-Tiyosemikarbazon Türevlerinin Miyeloid, Lenfoid Lösemi Hücreleri ve Akut Lenfoblastik Lösemi Hastalarının Periferik Kan Mononuklear Hücreleri Üzerine Sitotoksik Etkileri.
Çetin M. B., Karadenizli S., Kuruca D. S., Karalı N. L., Güzel Akdemir Ö., Akgün Dar K., et al.
III. Multidisipliner Kanser Araştırma Sempozyumu Teorik Metot Çalıştayı, Bursa, Turkey, 14 - 17 March 2010, pp.40
2009
2009Synthesis and characterization of 5-chloro-1H-indole-2,3-dione 3-thiosemicarbazone derivatives
ERMUT G., KARALI N. L.
9th International Symposium on Pharmaceutical Sciences, Ankara, Turkey, 23 - 26 June 2009, pp.1
2007
2007Characterization and Antituberculosis Activity of Spiroindolinones
KARALI N. L., GÜZEL Ö., Salman A.
5th International Symposium on Pharmaceutical Chemistry, İstanbul, Turkey, 5 - 07 September 2007, pp.1
2006
2006C - H•••F , N / C - H•••S and C-H•••p Interactions in 5-fluoro-1H-indole- 2,3-dione-3-thiosemicarbazones
Özbey S., Kaynak B., KARALI N. L., Gürsoy A.
23rd European Crystallographic Meeting, ECM23, Leuven, Belgium, 6 - 11 August 2006, pp.62
2002
2002Synthesis and primary cytotoxicity evaluation of 3-[[3-phenyl-4(3H)-quinazolinone-2-yl)mercaptoacetyl]hydrazono]-1H-2-indolinones
Gürsoy A., KARALI N. L.
1st International Meeting on Medicinal and Pharmaceutical Chemistry, Ankara, Turkey, 25 - 28 September 2002, pp.1
2002
2002Synthesis and antimicrobial activity of new 4-thiazolidinone and 2-thioxo-4,5-imidazolidinedione derivatives of 5-nitro-1H-2-indolinones
Gürsoy A., Terzioğlu N., KARALI N. L., ÖTÜK G.
17th International Symposium on Medicinal Chemistry, Barcelona, Spain, 1 - 05 September 2002, pp.2
2002
2002Synthesis and antimicrobial activity of some benzazole derivatives
KARALI N. L., Gürsoy A., Cesur N., Ateş Ö., Özden S., ÖTÜK G., et al.
17th International Symposium on Medicinal Chemistry, Barcelona, Spain, 1 - 05 September 2002, pp.1
2001
2001Synthesis and antitubercular activity of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazolin-2-one benzylidenehydrazones,
KARALI N. L., KOCABALKANLI A. Ş., Gürsoy A., Ateş Ö.
International Symposium on Pharmaceutical Chemistry, İstanbul, Turkey, 17 - 19 September 2001, pp.1
1999
19994-(3-Coumarinyl)-4-thiazolin-2-one benzylidene-hydrazones with antituberculosis activity
Gürsoy A., KARALI N. L.
2nd International Symposium on Pharmaceutical Chemistry, Ankara, Turkey, 22 - 24 September 1999, pp.17
1999
1999Synthesis and pharmacology of new dithiocarbamic acid esters derived from phenothiazine and diphenylamine
KARALI N. L., Apak İ., Özkırımlı S., Gürsoy A., Özdemir O., Doğan S. U.
59th International Congress of FIP, Barcelona, Spain, 5 - 10 September 1999, pp.49
1997
1997Simultaneous determination of medazepam and hyoscine butylbromide in tablets by second-derivative ultraviolet spectrometry
KARALI N. L., Özkırımlı S., Gürsoy A.
5th International Symposium on Pharmaceutical Sciences, Ankara, Turkey, 24 - 27 June 1997, pp.108
1994
1994Synthesis and antifungal activity of new carbamodithioic acid esters derived from 3-acetylcoumarin
Gürsoy A., Ateş Ö., Cesur N., KARALI N. L.
First International Meeting on Pharmacy and Pharmaceutical Sciences, İstanbul, Turkey, 4 - 07 September 1994, pp.174
1993
1993Synthesis of novel acylthiosemicarbazides and thiazolidones as possible anticonvulsants
Gürsoy A., KARALI N. L.
World Congress of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan, 6 - 10 September 1993, pp.86
1990
1990Synthesis and characterization of some 3-acetylcoumarin derivatives
Gürsoy A., KARALI N. L.
50th International Congress of F.I.P., İstanbul, Turkey, 3 - 07 September 1990, pp.217
Books & Book Chapters
2021
2021Narkotik (Santral Etklili) Analjezikler (Opiat Analjezikler)
Karalı N. L.
in: Medisinal Kimya, Mehmet Alp, Editor, Akademisyen Kitabevi, Ankara, pp.683-719, 2021
2019
2019Opioit Analjezikler ve Antagonistleri
Karalı N. L.
in: Foye Medisinal Kimya Temel İlkeleri, Algül Ö.,Boleli K., Editor, Ankara Nobel Tıp Kıtabevi, Ankara, pp.182-199, 2019
Other Publications
Supported Projects
2024 - Continues
2024 - ContinuesTirozin Kinaz İnhibitörü Arilsülfonamid Artığı Taşıyan 2indolinon Türevlerinin Tasarımı Sentezi ve Biyolojik Etkilerinin İncelenmesi
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), TEMİZER A. B.
2023 - 2026
2023 - 2026İlaç adayı tirozin kinaz inhibitörü yeni 2-indolinon türevlerinin tasarımı sentezi, inhibitör etkilerinin ve etki mekanizmalarının incelenmesi
Project Supported by Higher Education Institutions
Karalı N. L. (Executive), Öztay F., Bolkent Ş., Yıldırım M., Erol A., Genç Akar Ö., et al.
2022 - 2025
2022 - 2025Tirozin Kinaz İnhibitörü 2-İndolinon Türevleri: Tasarım, Sentez, Sitotoksisite, Etki Mekanizması ve Reseptör Kinaz İnhibitör Etki Tayini
TUBITAK Project
Karalı N. L. (Executive), Cihan Üstündağ G., Bolkent Ş., Kuruca D. S., Öztay F., Sancar S., et al.
2023 - 2024
2023 - 2024Naftalen Artığı Taşıyan Yeni 1H- indol-2,3-dion Türevlerinin Sentezi, Yapı Tayini ve Antiviral Etkilerinin İncelenmesi
TUBITAK Project
Karalı N. L., Alboru Z. B.(Executive)
2023 - 2024
2023 - 2024Yeni 1-Naftalenilmetil-1H-indol-2,3-dion Türevleri Sentez, Yapı ve Antiviral Etki Tayinleri
TUBITAK Project
Karalı N. L., Sağ F.(Executive), Nalça İ.
2020 - 2024
2020 - 2024Tirozin Kinaz İnhibitörü 3-Ariliden-2-indolinon Bileşiklerinin Tasarımı, Sentezi ve Biyolojik Etkilerinin İncelenmesi
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), CİNEK T., ÖZEN EROĞLU G., KOULANI T., CİHAN ÜSTÜNDAĞ G., KURUCA D. S., et al.
2020 - 2023
2020 - 2023Benzotiyazolin Artığı Taşıyan Spiroindolinonlar: Sentez Yapı Tayini ve Biyolojik Etki Araştırmaları
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), TEMİZER A. B., ÖZSOY N., ARDA E. Ş. N., ANDAÇ Ö., KARABAĞ N., et al.
2020 - 2023
2020 - 2023KimDil: Kimyasal Dilde Makine Çevirisi ile Hedef Odaklı İlaç Tasarımı
TUBITAK Project
Özgür Türkmen A.(Executive), Karalı N. L., Özkırımlı Ölmez E., Ülgen Ş. K.
2019 - 2023
2019 - 2023NOVEL NON-NUCLEOSIDE HEPATITIS-C RNA-DEPENDENT RNA POLYMERASE (NS5B)INHIBITORS THAT BIND TO THE ALLOSTERIC THUMB SITE II
TUBITAK Project
KARALI N. L., Gezginci M. H.(Executive), SOYLU ETER Ö., APAYDIN Ç. B.
2019 - 2022
2019 - 2022NOVEL NON-NUCLEOSIDE HEPATITIS-C RNA-DEPENDENT RNA POLYMERASE (NS5B) INHIBITORS THAT BIND TO THE ALLOSTERIC THUMB
TUBITAK Project
Karalı N. L.
2019 - 2021
2019 - 2021KimDil: Kimyasal Dilde Makine Çevirisi ile Hedef Odaklı İlaç Tasarımı
TUBITAK Project
Özgür Türkmen A.(Executive), Karalı N. L., Özkırımlı Ölmez E., Ülgen Ş. K.
2018 - 2021
2018 - 2021Sülfamoilfenil artığı taşıyan 1H-indol-2,3-dion 3-tiyosemikarbazon türevleri: Moleküler modelleme, sentez, yapı tayini, antikanser ve antiviral etki tayini
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), BOZDAĞ M., NAESENS L., CİHAN ÜSTÜNDAĞ G., GÖKTAŞ F., APAYDIN Ç. B., et al.
2019 - 2020
2019 - 2020Yeni 1H-indol-2,3-dion 3-[N-(4-sülfamoilfenil)tiyosemikarbazon] Türevlerinin N-Mannich Bazlarının Sentezi ve Yapı Tayini
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), TEMİZER A. B., YILDIRIM E. R.
2019 - 2020
2019 - 2020Yeni 1H-indol-2,3-dion 3-[N-(3-sülfamoil)feniltiyosemikarbazon] Türevlerinin N-Mannich Bazlarının Sentezi ve Yapı Tayini
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), ARSLANTÜRK E., ÖZGEN B.
2018 - 2019
2018 - 2019Benzotiyazol artığı taşıyan yeni spiroindolinonların sentezi ve yapı tayini
TUBITAK Project
KARALI N. L. (Executive), Şahin B.
2018 - 2019
2018 - 20193-Ariliden-2-indolinon türevlerininin sentezi ve yapı tayini
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), CİNEK T., CAMCI M.
2017 - 2019
2017 - 2019İnterlökin-1 inhibitörü ilaç adayı yeni 5-(triflorometoksi)-1H-indol-2,3-dion 3-(4-feniltiyosemikarbazon) türevlerinin tasarımı, sentezi ve etkinliklerinin incelenmesi
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), SOYLU Ö.
2016 - 2019
2016 - 2019Özgün 2-indolinon bileşiklerinin anti-interlökin 1 ve kemoterapötik ekinlik gösteren ilaçlar olarak geliştirilmesi
TUBITAK Project
KARALI N. L. (Executive), CİHAN ÜSTÜNDAĞ G., GÖKTAŞ F., Erman B.(Executive), Müftüoğlu M.(Executive), Erman B., et al.
2016 - 2019
2016 - 2019Cry proteini yıkımını hızlandıran sentetik moleküllerin kanser tedavisinde kullanımı
TUBITAK Project
Karalı N. L., Pala Kara Z., Okyar A., Türkay M.(Executive), Öztürk N.
2017 - 2018
2017 - 20183-Sülfamoilfenil artığı taşıyan 1H-indol-2,3-dion 3-tiyosemikarbazon türevlerinin sentezi, CYP ve aromataz enzim aktivitelerinin tayini
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), SOYLU Ö., ÖZSOY N., GÜRER-ORHAN H., İNCE E., ERASLAN ELMA P., et al.
2017 - 2018
2017 - 2018Yeni 3ariliden2indolinon türevlerinin sitotoksik ve tirozin kinaz inhibitör etkilerinin belirlenmesi
Project Supported by Higher Education Institutions
SANCAR S. (Executive), KARALI N. L., BOLKENT Ş., ÖZTAY F., CİHAN ÜSTÜNDAĞ G., KAYALAR Ö.
2016 - 2018
2016 - 2018Sülfonamid grubu içeren yeni tiyoüre türevlerinin sentezi ve yapı tayini
Project Supported by Higher Education Institutions
GÜZEL AKDEMİR Ö. (Executive), KARALI N. L., DEMİR K.
2017 - 2017
2017 - 2017Molecular modelling studies to guide synthesis programs of new thiourea compounds as putative inhibitors of hCA IX/XII and VcCA
Project Supported by Higher Education Institutions
GÜZEL AKDEMİR Ö. (Executive), AKDEMİR A., KARALI N. L., DEMİR K.
2017 - 2017
2017 - 2017Yeni 1-sübstitüe 1H-indol-2,3-dion ve sülfamoil artığı taşıyan 1H-indol-2,3-dion-3-tiyosemikarbazon türevleri ve sentez yöntemleri
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), ERASLAN P., GÖKTAŞ F., CİHAN ÜSTÜNDAĞ G.
2016 - 2017
2016 - 20171-Benzil-1H-indol-2,3-dion Türevlerinin Sentezi ve Karakterizasyonu
TUBITAK Project
KARALI N. L. (Executive), Taşdan Y.
2016 - 2017
2016 - 20171-Benzil-1H-indol-2,3-dion Türevlerinin Sentezi ve Karakterizasyonu
TUBITAK Project
KARALI N. L. (Executive), Taşdan Y.
2015 - 2017
2015 - 20173-Sülfamoilfenil Artığı Taşıyan 1H-İndol-2,3-Dion 3-Tiyosemikarbazon Türevleri: Sentez, Yapı Tayini, Moleküler Modelleme ve Biyolojik Aktivite Tayini
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), ERASLAN P., AKDEMİR A.
2016 - 2016
2016 - 2016Yeni 1-sübstitüe 1H-indol-2,3-dion bileşikleri ve sentez yöntemleri
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), ERASLAN P., GÖKTAŞ F., CİHAN ÜSTÜNDAĞ G.
2016 - 2016
2016 - 2016Yeni sülfamoil artığı taşıyan 1H-indol-2,3-dion-3-tiyosemikarbazon türevleri ve sentez yöntemleri
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), GÖKTAŞ F., ERASLAN P.
2014 - 2016
2014 - 20161H-2-indolinon artığı taşıyan N-benzilüre türevlerinin sentezi
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), GÖKTAŞ F.
2013 - 2016
2013 - 2016Kaspaz-1 ve/veya kaspaz-3 inhibitörü 1H-İndol-2,3-dion 3-(N-sülfamoilfenil)tiyosemikarbazon türevleri: Tasarım, moleküler modelleme, sentez ve biyolojik inceleme
Project Supported by Higher Education Institutions
KARALI N. L. (Executive), GÖKTAŞ F., CİHAN ÜSTÜNDAĞ G., ERASLAN P., GÜL A., ERMAN B., et al.
2014 - 2015
2014 - 20155-Nitro-1H-indol-2,3-dion 3-tiyosemikarbazon türevlerinin N-Mannich bazlarının sentezi
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
2013 - 2013
2013 - 2013Antikanser ve antiviral etkili 1H-İndol-2,3-dion 3-[N-(4-sülfamoilfenil)tiyosemikarbazon] türevlerinin sentezi ve biyolojik incelemeleri
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
2009 - 2013
2009 - 20131H-İndol-2,3-dion 3-tiyosemikarbazon türevleri üzerinde çalışmalar
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
2011 - 2012
2011 - 20125-Kloro-1H-indol-2,3-dion 3-tiyosemikarbazon türevlerinin sentezi ve yapı tayini
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
2009 - 2010
2009 - 2010SPİRO[FURAN-2,3'-İNDOL]-3-KARBOKSİLAT TÜREVLERİNİN SENTEZİ VE YAPI TAYİNLERİ
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
2009 - 2010
2009 - 2010SPİROİNDOLİNONLARIN YAPI TAYİNLERİ VE ANTİOKSİDAN AKTİVİTELERİNİN ARAŞTIRILMASI
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
2008 - 2010
2008 - 20105-Klorobenzotiyazolin Artığı Taşıyan Spiroindolinonların Sentezi ve Antioksidan Etkilerinin İncelenmesi
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
2007 - 2009
2007 - 2009SPİROİNDOLİNONLARIN SENTEZİ VE YAPI TAYİNİ
Project Supported by Higher Education Institutions
KARALI N. L. (Executive)
Patent
2023
20235-FLUORO/(TRIFLUOROMETHOXY)-2-INDOLINONE DERIVATIVES-EPO
Patent
Pending / Applied, The Invention Recourse Number: EP/20728576.8 , Standard Registration
2023
2023NEW 3-ARYLIDEN-2-INDOLINONE DERIVATIVES FOR THERAPEUTIC PURPOSES
Patent
Pending / Applied, The Invention Recourse Number: PCT/TR2023/050966 , Standard Registration
2022
2022TERAPÖTİK AMAÇLI KULLANILMAK ÜZERE YENİ 3-ARİLİDEN-2-İNDOLİNON TÜREVLERİ
Patent
Pending / Applied, The Invention Recourse Number: TR 2022/014289 , Standard Registration
2020, 2022
2020, 2022New 3-Arylidene-2-Indolinone Dervatives
Patent
Registered / Approved, The Invention Registration Number: TR 2020 050104 , Standard Registration
2020
20205-Fluoro/(Trifluoromethoxy)-2-Indolinone Derivatives
Patent
Pending / Applied, The Invention Recourse Number: PCT/TR2020/050104 , Standard Registration
2019
2019Yeni sülfamoil artığı taşıyan 1H-indol-2,3-dion 3-tiyosemikarbazon türevleri ve sentez yöntemleri
Patent
Registered / Approved, The Invention Registration Number: C07D 209/40, C07D 209/38, C07C 337/08, C07C 311/16 , Standard Registration
2019
2019New 1-substituted 1H-indole-2,3-dione compounds ve synthesis methods
Patent
Registered / Approved, The Invention Registration Number: TR 2015 15912 A2 , Standard Registration
2016
20161H-indole-2,3-dione-3-thiosemicarbazone derivatives as interleukin-1 receptor antagonist
Patent
Pending / Applied, The Invention Recourse Number: TP16-431 , Standard Registration
2016
2016N-[(Aminosulfonyl)phenyl]2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-hydrazinecarbothioamide derivatives for treating cancer and immunological disorders
Patent
Pending / Applied, The Invention Recourse Number: PCT/TR2016/050491
Activities in Scientific Journals
2010 - Continues
2010 - ContinuesTürkiye Klinikleri Eczacılık Bilimleri
Advisory Committee Member
2013 - 2022
2013 - 2022Committee Member
2014 - 2018
2014 - 2018Marmara Pharmaceutical Journal
Advisory Committee Member
Memberships / Tasks in Scientific Organizations
2017 - Continues
2017 - ContinuesECZAKDER
Member
2015 - Continues
2015 - ContinuesUlusal Eczacılık Eğitimi Akreditasyon Kurulu
Board Member
2014 - Continues
2014 - ContinuesUlusal Eczacılık Eğitimi Akreditasyon Kurulu-Değerlendirme ve İzleme Ziyareti Komisyonu
Member
1998 - Continues
1998 - Continuesİstanbul Üniversitesi Öğretim Üyeleri Derneği
Member
1992 - Continues
1992 - ContinuesTürk Farmasötik ve Medisinal Kimya Derneği
Member
2011 - 2016
2011 - 2016İstanbul Üniversitesi, Geleneksel İlaçlar Araştırma ve Uygulama Merkezi
Board Member
Scientific Refereeing
April 2016
April 2016TUBITAK Project
March 2016
March 2016TUBITAK Project
January 2016
January 2016TUBITAK Project
July 2015
July 2015TUBITAK Project
May 2015
May 2015TUBITAK Project
July 2014
July 2014TUBITAK Project
June 2013
June 2013TUBITAK Project
May 2013
May 2013TUBITAK Project
October 2012
October 2012TUBITAK Project
September 2011
September 2011TUBITAK Project
June 2010
June 2010TUBITAK Project
January 2010
January 2010TUBITAK Project
April 2009
April 2009TUBITAK Project
October 2008
October 2008TUBITAK Project
October 2008
October 2008TUBITAK Project
Scientific Consultations
2018 - Continues
2018 - ContinuesProject Consultancy
TÜBİTAK
Istanbul University, Faculty Of Pharmacy , Department of Professional Pharmaceutical Sciences, Turkey
2016 - 2017
2016 - 2017Project Consultancy
TÜBİTAK
Istanbul University, Faculty Of Pharmacy , Department of Professional Pharmaceutical Sciences, Turkey
Congress and Symposium Activities
01 April 2018 - 01 April 2018
01 April 2018 - 01 April 2018V. Ulusal Farmasötik Kimya Kogresi
Attendee
Erzurum-Turkey
01 April 2017 - 01 April 2017
01 April 2017 - 01 April 2017Uluslararası İlaç ve Eczacılık Kongresi-İVEK
Attendee
İstanbul-Turkey
01 June 2016 - 01 June 2016
01 June 2016 - 01 June 20167th European Congress of Pharmacology EPHAR 2016
Attendee
İstanbul-Turkey
01 June 2013 - 01 June 2013
01 June 2013 - 01 June 2013Challenges in Organic & Bioorganic Chemistry: 14th Tetrahedron Symposium
Attendee
Viyana-Austria
01 May 2013 - 01 May 2013
01 May 2013 - 01 May 2013Farmasötik Bakım Süreci ve Akılcı İlaç Kullanımında Eczacının Rolü
Attendee
İstanbul-Turkey
01 September 2012 - 01 September 2012
01 September 2012 - 01 September 20123. Ulusal Farmasötik Kimya Kongresi
Attendee
Malatya-Turkey
01 June 2009 - 01 June 2009
01 June 2009 - 01 June 20099th International Symposium on Pharmaceutical Sciences
Attendee
Ankara-Turkey
01 September 2007 - 01 September 2007
01 September 2007 - 01 September 20075th International Symposium on Pharmaceutical Chemistry
Attendee
İstanbul-Turkey
01 September 2002 - 01 September 2002
01 September 2002 - 01 September 200217th International Symposium on Medicinal Chemistry
Attendee
Barcelona-Spain
01 September 2002 - 01 September 2002
01 September 2002 - 01 September 20021st International Meeting on Medicinal and Pharmaceutical Chemistry
Attendee
Ankara-Turkey
01 September 2001 - 01 September 2001
01 September 2001 - 01 September 2001International Symposium on Pharmaceutical Chemistry
Attendee
İstanbul-Turkey
01 September 1999 - 01 September 1999
01 September 1999 - 01 September 19992nd International Symposium on Pharmaceutical Chemistry
Attendee
Ankara-Turkey
01 June 1997 - 01 June 1997
01 June 1997 - 01 June 19975th International Symposium on Pharmaceutical Sciences
Attendee
Ankara-Turkey
01 September 1994 - 01 September 1994
01 September 1994 - 01 September 1994First International Meeting on Pharmacy and Pharmaceutical Sciences
Attendee
İstanbul-Turkey
01 September 1993 - 01 September 1993
01 September 1993 - 01 September 1993World Congress of Pharmacy and Pharmaceutical Sciences
Attendee
Tokyo-Japan
01 September 1990 - 01 September 1990
01 September 1990 - 01 September 199050th International Congress of F.I.P.
Attendee
İstanbul-Turkey
Citations
Total Citations (WOS): 1108
h-index (WOS): 17
Jury Memberships
June-2018
June 2018Doctorate
Doktora Tez Savunma Sınavı - İstanbul Üniversitesi Eczacılık Fakültesi
April-2018
April 2018Doctorate
Doktora Tez Savunma Sınavı - İstanbul Üniversitesi Eczacılık Fakültesi
December-2017
December 2017Associate Professor Exam
Doçentlik Sınav Jürisi - İstanbul Üniversitesi Eczacılık Fakültesi
December-2017
December 2017Associate Professor Exam
Doçentlik Sınav Jürisi - İstanbul Üniversitesi Eczacılık Fakültesi
December-2017
December 2017Associate Professor Exam
Doçentlik Sınav Jürisi - İstanbul Üniversitesi Eczacılık Fakültesi
December-2017
December 2017Associate Professor Exam
Doçentlik Sınav Jürisi - İstanbul Üniversitesi Eczacılık Fakültesi
December-2017
December 2017Associate Professor Exam
Doçentlik Sınav Jürisi - İstanbul Üniversitesi Eczacılık Fakültesi
November-2017
November 2017Doctorate
Doktora Tez Savunma Sınavı - İstanbul Üniversitesi Eczacılık Fakültesi
November-2017
November 2017Doctorate
Doktora Tez Savunma Sınavı - İstanbul Üniversitesi Eczacılık Fakültesi
July-2017
July 2017Post Graduate
Yüksek lisans tez savunma jürisi - Boğaziçi Üniversitesi Fen Bilimleri Enstitüsü
July-2016
July 2016Doctorate
Tez savunma jürisi - Marmara Üniversitesi Eczacılık Fakültesi
May-2016
May 2016Appointment to Academic Staff-Assistant Professorship
Profesör jürisi - İstanbul Üniversitesi Eczacılık Fakültesi
March-2016
March 2016Associate Professor Exam
Doçentlik Sınav Jürisi - Üniversitelerarası Kurul
July-2015
July 2015Post Graduate
Yüksek Lisans Tez Savunma - İstanbul Üniversitesi Eczacılık Fakültesi
June-2015
June 2015Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi Eczacılık Fakültesi
June-2015
June 2015Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi Eczacılık Fakültesi
June-2015
June 2015Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi Eczacılık Fakültesi
May-2015
May 2015Appointment to Academic Staff-Assistant Professorship
Araştırma Görevlisi Kadro Sınavı - İstanbul Üniversitesi Eczacılık Fakültesi
January-2015
January 2015Appointment to Academic Staff-Assistant Professorship
Yardımcı Doçentlik Atama - İstanbul Üniversitesi Eczacılık Fakültesi
September-2014
September 2014Doctoral Examination
Doktora Yeterlilik - Marmara Üniversitesi
June-2014
June 2014Post Graduate
Yüksek Lisans Tez Savunma - İstanbul Üniversitesi Eczacılık Fakültesi
June-2014
June 2014Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi Eczacılık Fakültesi
June-2014
June 2014Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi Eczacılık Fakültesi
March-2013
March 2013Appointment to Academic Staff-Assistant Professorship
Yardımcı Doçentlik Atama - Marmara Üniversitesi
January-2013
January 2013Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi
November-2012
November 2012Associate Professor Exam
Doçentlik Dosyası İnceleme - Ege Üniversitesi
November-2012
November 2012Appointment to Academic Staff-Professorship
Profesör kadrosuna atanma - Yeni Yüzyıl Üniversitesi
July-2012
July 2012Doctorate
Doktora Tez Savunma Jürisi - İstanbul Üniversitesi
June-2012
June 2012Associate Professor Exam
Doçentlik Sınav Jürisi - Hacettepe Üniversitesi
June-2012
June 2012Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi
June-2012
June 2012Doctoral Examination
Doktora Yeterlilik - İstanbul Üniversitesi
September-2011
September 2011Post Graduate
Tez Savunma Jürisi - Marmara Üniversitesi
July-2011
July 2011Doctorate
Tez Savunma Jürisi - Marmara Üniversitesi
June-2011
June 2011